EHNA HYDROCHLORIDE

EHNA HYDROCHLORIDE Suppliers list
Company Name: NewCan Biotech Limited
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Products Intro: Product Name:6-amino-β-hexyl-α-methyl-,(αR,βS)-rel-9H-Purine-9-ethanol
CAS:51350-19-7
Purity:97% Package:mgs,gs,kgs
Company Name: Aladdin Scientific
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Products Intro: Product Name:EHNA hydrochloride
CAS:51350-19-7
Purity:>=98% Package:$379.9/10mg;Bulk package Remarks:98%
Company Name: J & K SCIENTIFIC LTD.  
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Products Intro: Product Name:EHNA.HCl
CAS:51350-19-7
Package:10mg, 50mg
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
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Products Intro: Product Name:EHNA hydrochloride;erythro-9-(2-Hydroxy-3-nonyl)adeninehydrochloride
CAS:51350-19-7
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Company Name: Shanghai Aladdin Bio-Chem Technology Co.,LTD  
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Products Intro: Product Name:EHNA hydrochloride
CAS:51350-19-7
Purity:>=98% Package:10mg/RMB 1029.90
EHNA HYDROCHLORIDE Basic information
Product Name:EHNA HYDROCHLORIDE
Synonyms:9-ERYTHRO-(2-HYDROXY-3-N-NONYL) ADENINE HYDROCHLORIDE;ERYTHRO-9-(2-HYDROXY-3-NONYL)ADENINE, HCL;ERYTHRO-9-(2-HYDROXY-3-NONYL)ADENINE HYDROCHLORIDE;ERYTHRO-9-AMINO-BETA-HEXYL-ALPHA-METHYL-9H-PURINE-9-ETHANOL HYDROCHLORIDE;EHNA;EHNA HCL;EHNA HYDROCHLORIDE;MEP1 HYDROCHLORIDE
CAS:51350-19-7
MF:C14H23N5O
MW:277.37
EINECS:
Product Categories:Bases & Related Reagents;Inhibitors;Nucleotides;Cyclic Nucleotide related;All Inhibitors
Mol File:51350-19-7.mol
EHNA HYDROCHLORIDE Structure
EHNA HYDROCHLORIDE Chemical Properties
Melting point 183~184℃
storage temp. 0-6°C
solubility DMSO: 12 mg/mL
form solid
color white
Stability:Stable for 2 years as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference51350-19-7
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
EHNA HYDROCHLORIDE Usage And Synthesis
DescriptionEHNA (51350-19-7) inhibits phosphodiesterase 2 (PDE2) (IC50 = 0.8 – 5.5 μM in a variety of tissues and species) over PDE1, PDE3, or PDE4 (IC50 values > 100 μM).1,2 It also inhibits adenosine deaminase (ADA), IC50 = 1.2 and 1.5 μM in human RBCs and astrocytoma cells, respectively3, which may be responsible for its ability to induce apoptosis in malignant pleural mesothelioma cell lines4. Because it blocks breakdown of adenosine to inosine and hypoxanthine, EHNA prevents formation of free radical substrates, protecting against cardiac reperfusion-mediated injury.5 It inhibits differentiation and maintains expression of pluripotency markers in hESCs, but not through inhibition of PDEs or ADA.6
Chemical PropertiesWhite Solid
UsesA potent inhibitor of phosphodiesterase II (PDE II) (IC50=800nM). Does ot inhibit other PDE isozymes (IC50>100uM). Inhibits the retrograde transport motor, dynein. Also inhibits adenosine deaminase (Ki=4nM)
Uses9-erythro-(2-Hydroxyl-3-nonyl)adenine is an intermediate in the synthesis of potent inhibitor of phosphodiesterase II.
DefinitionChEBI: (2R,3S)-EHNA is eHNA of absolute configuration 2R,3S. Selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC50 = 0.8 - 4 mM). Also a potent inhibitor of adenosine deaminase. It has a role as an EC 3.5.4.4 (adenosine deaminase) inhibitor and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor. It is a conjugate base of a (2R,3S)-EHNA(1+). It is an enantiomer of a (2S,3R)-EHNA.
Biological ActivitySelective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC 50 = 0.8 - 4 mM). Also a potent inhibitor of adenosine deaminase.
ReferencesPodzuweit et al. (1995), Isoenzyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythron-9-(2-hydroxy-3-nonyl) adenine; Cell Signal., 7 733 Méry et al. (1995), Erythro-9-(2-hydroxy-3-nonyl)adenine inhibits cyclic GMP-stimulated phosphodiesterase in isolated cardiac myocytes; Mol. Pharmacol., 48 121 Barankiewicz et al. (1997), Regulation of adenosine concentration and cytoprotective effects of novel reversible adenosine deaminase inhibitors; J. Pharmacol. Exp. Ther., 283 1230 Nakajima et al. (2015), Adenosine deaminase inhibitor EHNA exhibits a potent anticancer effect against malignant pleural mesothelioma; Cell Physiol. Biochem., 35 51 Abd-Elfattah and Wechsler (1994), Separation between ischemic and reperfusion injury by site specific entrapment of endogenous adenosine and inosine using NBMPR and EHNA; Card. Surg., 9 387 Burton et al. (2010), Erythro-9-(2-hydroxy-3-nonyl)adenine(EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells; Biochem. J., 432 575
EHNA HYDROCHLORIDE Preparation Products And Raw materials
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