相思豆毒素
| 中文名称 | 相思豆毒素 |
|---|---|
| 中文同义词 | 相思豆毒素;相思豆毒素,L-红豆碱;L-红豆碱;L-ABRINE 相思豆毒素;NΑ-甲基-L-色氨酸;天麻碱;L-(+)-相思子碱;相思豆毒素标准品 |
| 英文名称 | L-ABRINE |
| 英文同义词 | H-METRP-OH;L-ABRINE;ABRINE;ABRINE, L-;N-METHYLTRYPTOPHAN;N-ME-TRP-OH;N-ME-TRP-OH HCL;N-ME-TRYPTOPHAN |
| CAS号 | 526-31-8 |
| 分子式 | C12H14N2O2 |
| 分子量 | 218.25 |
| EINECS号 | 208-388-5 |
| 相关类别 | 标准品;非天然氨基酸衍生物;植物提取物;中药对照品;医药原料药;标准品 -中药标准品;医药原料;Indoles;Tryptophans;Amino Acid Derivatives;Peptide Synthesis;Tryptophan |
| Mol文件 | 526-31-8.mol |
| 结构式 |  |
相思豆毒素 性质
| 熔点 | >300 °C (dec.)(lit.) |
|---|---|
| 比旋光度 | D21 +44° (0.28 g in 10 ml 0.5N HCl) |
| 沸点 | 358.94°C (rough estimate) |
| 密度 | 1.272±0.06 g/cm3 (20 ºC 760 Torr) |
| 折射率 | 65 ° (C=1, 0.5mol/L NaOH) |
| 储存条件 | under inert gas (nitrogen or Argon) at 2–8 °C |
| 溶解度 | H2O：2 mg/mL（9.16 mM；超声并用 NaOH 将 pH 调节至 10） |
| 形态 | 水晶。 |
| 酸度系数(pKa) | 2.32±0.10(Predicted) |
| 颜色 | 米白色至浅黄色 |
| 旋光性 (optical activity) | [α]20/D +65°, c = 1 in 0.5 M NaOH |
| Merck | 14,10 |
| BRN | 86638 |
| CAS 数据库 | 526-31-8(CAS DataBase Reference) |
L-(+)-Abrine is a marker for abrin poisoning. A strong indication for abrin poisoning is the presence of the chemical maker L-(+)-Abrine, which can survive metabolism in significant amounts making it detectable in human urine.
Abrin is a toxic protein found in the jequirity seed. L-(+)-Abrine (L-Abrine) is also found in the jequirity seed and can be used as a biomarker for abrin exposure. An animal study is designed to monitor the excretion and recovery of L-(+)-Abrine in 20 rats. The animals are exposed to one of three concentrations of L-(+)-Abrine, a single high concentration of L-tryptophan, or no agent (control). The low L-(+)-Abrine dose corresponds to 0.63 LD 50 i.p. abrin in mice, assuming a concentration ratio of 1:4 of abrin to L-(+)-Abrine and an LD 50 for abrin of 20 μg/kg. The mid and high L-(+)-Abrine (250 and 400 μg/kg) doses are included to ensure that the target analyte can be detected and tracked over the course of the experiment.
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