| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:EO 1428;(2-Methylphenyl)-[4-[(2-aMino-4-broMophenyl)aMino]-2-chlorophenyl]Methanone
CAS:321351-00-2
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
EMMX Biotechnology LLC
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| Tel: |
888-539-0666 |
| Email: |
info@emmx.com |
| Products Intro: |
Product Name:EO 1428
CAS:321351-00-2
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| | EO 1428 Basic information |
| Product Name: | EO 1428 | | Synonyms: | p38 MAP Kinase Inhibitor VIII;EO 1428;(2-Methylphenyl)-[4-[(2-amino-4-bromophenyl)amino]-2-chlorophenyl]methanone;p38 MAPK Inhibitor VIII;Methanone, [4-[(2-amino-4-bromophenyl)amino]-2-chlorophenyl](2-methylphenyl)- | | CAS: | 321351-00-2 | | MF: | C20H16BrClN2O | | MW: | 415.71 | | EINECS: | | | Product Categories: | | | Mol File: | 321351-00-2.mol |  |
| | EO 1428 Chemical Properties |
| storage temp. | Store at +4°C | | solubility | Soluble to 100 mM in DMSO and to 50 mM in ethanol | | form | Powder |
| | EO 1428 Usage And Synthesis |
| Uses | EO 1428 is a p38 MAP kinase inhibitor with high antiinflammatory activity. | | Definition | ChEBI: [4-(2-amino-4-bromoanilino)-2-chlorophenyl]-(2-methylphenyl)methanone is a member of benzophenones. | | Biological Activity | Selective inhibitor of p38 α and p38 β 2 that displays no activity at p38 γ , p38 δ , ERK1/2 and JNK1. Inhibits production of inflammatory cytokines including IL-8, TNF- α , IL-6, IL-1 β and IL-10 (IC 50 values are 4, 5, 17, 30 and 74 nM respectively). Displays anti-inflammatory activity in murine models of acute and chronic dermatitis. | | storage | Store at +4°C |
| | EO 1428 Preparation Products And Raw materials |
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