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Alabiochem Tech.Co., Ltd.
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Product Name:Fmoc-norArg(Pbf)-OH
CAS:1313054-32-8
Purity:>98% Package:5g;25g;100g;250g;1kg Remarks:>150g
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| | Fmoc-norArg(pbf)-OH Basic information |
| Product Name: | Fmoc-norArg(pbf)-OH | | Synonyms: | Fmoc-norArg(pbf)-OH;(2S)-4-[[amino-[(2,2,4,6,7-pentamethyl-3~{H}-1-benzofuran-5-yl)sulfonylamino]methylidene]amino]-2-(9~{H}-fluoren-9-ylmethoxycarbonylamino)butanoic acid;(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-{N'-[(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)sulfonyl]carbamimidamido}butanoic acid;Butanoic acid, 4-[[[[(2,3-dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]amino]-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (2S)-;(2S)-4-[[[[(2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]amino]-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]butanoic acid;(S,E)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(N'-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)formohydrazonamido)butanoic acid;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)butanoic acid;(S)-2-(Fmoc-amino)-4-[[amino(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-sulfonamido)methylene]amino]butanoic Acid | | CAS: | 1313054-32-8 | | MF: | C33H38N4O7S | | MW: | 634.74 | | EINECS: | | | Product Categories: | amino acid;amino acids | | Mol File: | 1313054-32-8.mol |  |
| | Fmoc-norArg(pbf)-OH Chemical Properties |
| density | 1.38±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 3.75±0.10(Predicted) | | InChIKey | FWOIXFWITXCUKI-NDEPHWFRSA-N | | SMILES | C(O)(=O)[C@@H](NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)CCNC=NNS(C1=C(C)C(C)=C2OC(C)(C)CC2=C1C)(=O)=O |
| | Fmoc-norArg(pbf)-OH Usage And Synthesis |
| Chemical Properties |
The IUPAC Name of Fmoc-norArg(pbf)-OH is rac-(R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)propanoic acid. Pbf is 2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl.
In addition, conjugation of Arg-containing peptides is difficult due to the steric hindrance of Pbf in a side chain as a protecting group, resulting in low peptide yield or even synthesis failure[1].
| | References | [1] Keiichi Yamada . “Efficient solid-phase synthesis of cyclic RGD peptides under controlled microwave heating.” Tetrahedron Letters 53 9 (2012): Pages 1066-1070.
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| | Fmoc-norArg(pbf)-OH Preparation Products And Raw materials |
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