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| N3-PEG3-tBu Basic information |
Product Name: | N3-PEG3-tBu | Synonyms: | N3-PEG3-CH2CH2COOtBu;N3-PEG3-tBu;N3-PEG3-CH2CH2COOtBu;3-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]propanoic acid 1,1-dimethylethyl ester;tert-butyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate;Azido-PEG3-COOtBu;tert-Butyl 3-(2-(2-(2-azidoethoxyl)ethoxy)ethoxy)propanoate;N3-?PEG3-?t-?butyl ester | CAS: | 252881-73-5 | MF: | C13H25N3O5 | MW: | 303.3547 | EINECS: | | Product Categories: | SiChem;peg | Mol File: | 252881-73-5.mol | ![N3-PEG3-tBu Structure](CAS/20150408/GIF/252881-73-5.gif) |
| N3-PEG3-tBu Chemical Properties |
form | Liquid | color | Colorless to light yellow |
| N3-PEG3-tBu Usage And Synthesis |
Description | Azido-PEG3-t-butyl ester is a click chemistry reagent. The hydrophilic PEG spacer increases solubility in aqueous media. The azide (N3) group canis reactive with alkyne, such as BCN, DBCO via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | Uses | Azido-PEG3-t-butyl Ester is used as a linker in the conjugation of peptides. | Biological Activity | N3-PEG3-tBu is a cleavable ADC linker containing 3-unit PEG, which can be used to synthesize antibody drug conjugates (ADC). It is also a PROTAC linker, belonging to the PEG and Alkyl/ether classes, which can be used to synthesize PROTAC molecules. | in vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. | target | PEGs | Alkyl/ether | Cleavable | |
| N3-PEG3-tBu Preparation Products And Raw materials |
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Tag:N3-PEG3-tBu(252881-73-5)
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