CINACIGUAT
| 中文名称 | CINACIGUAT |
|---|---|
| 中文同义词 | GUANYLATE CYCLASE激活剂(CINACIGUAT);4-[[(4-羧基丁基)[2-[2-[[4-(2-苯基乙基)苯基]甲氧基]苯基]乙基]氨基]甲基]苯甲酸;化合物CINACIGUAT;4-(((4-羧丁基)(2((4-苯乙基苄基)氧基)苯乙基)氨基)甲基)苯甲酸;CINACIGUAT,鸟苷酸环化酶 (GC) 活化剂;BAY 58-2667游离碱 |
| 英文名称 | 4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid |
| 英文同义词 | 4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid;BAY 58-2667;Cinaciguat;4-[[(4-Carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]-benzoic acid;Cinaciguat BAY-58-2667;CS-778;Benzoic acid, 4-[[(4-carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]-;4-(((4-Carboxybutyl)(2-((4-phenethylbenzyl)oxy)phenethyl)amino)methyl)benzoic acid |
| CAS号 | 329773-35-5 |
| 分子式 | C36H39NO5 |
| 分子量 | 565.7 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂;小分子抑制剂，天然产物;细胞生物学试剂;Inhibitors |
| Mol文件 | 329773-35-5.mol |
| 结构式 |  |
CINACIGUAT 性质
| 储存条件 | Inert atmosphere,Store in freezer, under -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 粉末 |
Cinaciguat (10 μM) significantly enhances intracellular cGMP generation. Cinaciguat does not dose-dependent effects on cell contraction and calcium transients.
Cinaciguat (10 mg/kg/day, p.o.) treatment in diabetic rats does not influence blood glucose levels, but leads to attenuated water intake. Cinaciguat treatment alleviates diabetes mellitus related oxidative stress, protects against DM related alteration of the NO-sGC-cGMP-PKG signalling, and alleviates DM related myocardium hypertrophy and apoptosis. Cinaciguat (1-10-100 nM) induces concentration-dependent relaxations in strips from both WT and apo-sGC mice, but does not have any effect on phasic activity induced by PGF 2α in WT or apo-sGC strips.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-14181 | CINACIGUAT Cinaciguat | 329773-35-5 | 2mg | 620元 |
| 2024/04/30 | HY-14181 | CINACIGUAT Cinaciguat | 329773-35-5 | 5mg | 1300元 |