(+)-Blebbistatin 基本信息
中文名称 | (+)-Blebbistatin |
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中文同义词 | (+)-BLEBBISTATIN;(R)-(+)-BLEBBISTATIN,肌球蛋白II ATPASE抑制剂 |
英文名称 | (+)-Blebbistatin |
英文同义词 | (+)-Blebbistatin - CAS 1177356-70-5 - Calbiochem;4H-Pyrrolo[2,3-b]quinolin-4-one, 1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-1-phenyl-, (3aR)-;(+)Blebbistatin,(+) Blebbistatin |
CAS号 | 1177356-70-5 |
分子式 | C18H16N2O2 |
分子量 | 292.33 |
EINECS号 | |
相关类别 | Chiral Reagents;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Chiral Reagents, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals |
Mol文件 | 1177356-70-5.mol |
结构式 | ![]() |
(+)-Blebbistatin 性质
沸点 | 507.3±60.0 °C(Predicted) |
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密度 | 1.31±0.1 g/cm3(Predicted) |
储存条件 | -20C |
溶解度 | DMF:20mg/mL; DMF:PBS(pH 7.2)(1:1):0.5 mg/ml;二甲基亚砜:12.5mg/mL |
形态 | 黄色固体 |
酸度系数(pKa) | 11.15±0.20(Predicted) |
用途
Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100μM. A negative control for the (S)-(-)-Blebblastatin. [a]D= +110 (c= 1.21 CHCl3) (-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-on e