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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788 |
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| Products Intro: |
Product Name:(R)-(+)-Blebbistatin
CAS:1177356-70-5
Package:50Mg,5Mg
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| | (+)-Blebbistatin Basic information |
| Product Name: | (+)-Blebbistatin | | Synonyms: | (+)-Blebbistatin - CAS 1177356-70-5 - Calbiochem;4H-Pyrrolo[2,3-b]quinolin-4-one, 1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-1-phenyl-, (3aR)-;(+)Blebbistatin,(+) Blebbistatin | | CAS: | 1177356-70-5 | | MF: | C18H16N2O2 | | MW: | 292.33 | | EINECS: | | | Product Categories: | Chiral Reagents;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Chiral Reagents, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals | | Mol File: | 1177356-70-5.mol |  |
| | (+)-Blebbistatin Chemical Properties |
| Boiling point | 507.3±60.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | storage temp. | -20C | | solubility | DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 12.5 mg/ml | | form | Yellow solid | | pka | 11.15±0.20(Predicted) |
| | (+)-Blebbistatin Usage And Synthesis |
| Chemical Properties | Bright Yellow Solid | | Uses | Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100μM. A negative control for the (S)-(-)-Blebblastatin.
[a]D= +110 (c= 1.21 CHCl3)
(±)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one
Selective inhibitor of nonmuscle myosin II; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells. | | Definition | ChEBI: (R)-blebbistatin is the (R)-enantiomer of blebbistatin. It is a blebbistatin and a tertiary alpha-hydroxy ketone. | | storage | Store at +4°C |
| | (+)-Blebbistatin Preparation Products And Raw materials |
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