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1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2)

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1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2) Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:B-Rafinhibitor1
CAS:1191385-19-9
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471
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Products Intro: Product Name:1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2)
CAS:1191385-19-9
Purity:99% Package:5KG;1KG Remarks:1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2)
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
Email: support@targetmol.com
Products Intro: Product Name:Raf inhibitor 1 dihydrochloride；B-Raf inhibitor 1 dihydrochloride
CAS:1191385-19-9
Package:10 mg；100 mg；2 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:B-Raf inhibitor 1 dihydrochloride
CAS:1191385-19-9
Purity:97% Package:$147.9/5mg;$265.9/10mg;$644.9/25mg;$1159.9/50mg;$2086.9/100mg;Bulk package Remarks:97%
Company Name: Suzhou ARTK Medchem Co., Ltd.
Tel: +8618168183658
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Products Intro: Product Name:1,5-isoquinolinediamine,n1-(4-chlorophenyl)-6-methyl-n5-[3-(9h-purin-6-yl)-2-pyridinyl]-,hydrochloride(1:2)
CAS:1191385-19-9
Purity:0.98 Package:100KG;25KG;10KG;1KG
1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2) Basic information
Product Name:1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2)
Synonyms:MFCD18782676;B-Raf inhibitor 1 dihydrochloride;N5-(3-(9H-Purin-6-yl)pyridin-2-yl)-N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine dihydrochloride;N1-(4-Chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-1,5-isoquinolinediamine dihydrochloride;N1-(4-Chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridyl]isoquinoline-1,5-diamine dihydroc;1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2);B-Raf inhibitor 1 2HCl;N1-(4-CHLOROPHENYL)-6-METHYL-N5-[3-(9H-PURIN-6-YL)-2-PYRIDINYL]-1,5-ISOQUINOLINEDIAMINE 2HCL
CAS:1191385-19-9
MF:C26H21Cl3N8
MW:551.87
EINECS:
Product Categories:
Mol File:1191385-19-9.mol
1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2) Structure
1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2) Chemical Properties
storage temp. Store at -20°C
solubility Soluble in DMSO
form Powder
Safety Information
HS Code 2933998090
MSDS Information
1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2) Usage And Synthesis
Biological Activityb-raf inhibitor 1 is an inhibitor of b-raf kinase with ic50 values of 0.31μm and 0.72μm for cell proliferation, respectively in a375 and hct116 [1].b-raf is important in signal transduction and some mutant b-raf occurs in cancer cells. the most common mutation of these is v600e, which makes b-raf kinase constitutively active. b-raf inhibitor 1 belongs to the type iia inhibitors and binds to the dfg-out atp-binding site of b-raf. the selectivity of b-raf inhibitor 1 is less than of other type inhibitors. besides mutant b-raf, it can also inhibit wild type b-raf and other tyrosine kinase. in cells with wild type b-raf, b-raf inhibitor 1 can activate the raf-mek-erk signaling pathway via raf dimerization. the preclinical toxicity test shows b-raf inhibitor 1 can induce hyperplasia in a mouse model [1, 2].
in vitroB-Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC 50 s of 0.31 and 0.72 μM, respectively. B-Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif.
targetA375 proliferation
references[1] wang x, kim j. conformation-specific effects of raf kinase inhibitors. j med chem. 2012 sep 13;55(17):7332-41.
[2] smith al, demorin ff, paras na, huang q, petkus jk, doherty em, nixey t, kim jl, whittington da, epstein lf, lee mr, rose mj, babij c, fernando m, hess k, le q, beltran p, carnahan j. selective inhibitors of the mutant b-raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline. j med chem. 2009 oct 22;52(20):6189-92.
1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2) Preparation Products And Raw materials
Tag:1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2)(1191385-19-9) Related Product Information