B-Raf 抑制剂 1 二盐酸盐
| 中文名称 | B-Raf 抑制剂 1 二盐酸盐 |
|---|---|
| 中文同义词 | 化合物B-RAF INHIBITOR 1 DIHYDROCHLORIDE;N5-(3-(9H-嘌呤-6-基)吡啶-2-基)-N1-(4-氯苯基)-6-甲基异喹啉-1,5-二胺二盐酸盐;B-RAF 抑制剂 1 二盐酸盐 |
| 英文名称 | 1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2) |
| 英文同义词 | MFCD18782676;B-Raf inhibitor 1 dihydrochloride;N5-(3-(9H-Purin-6-yl)pyridin-2-yl)-N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine dihydrochloride;N1-(4-Chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-1,5-isoquinolinediamine dihydrochloride;N1-(4-Chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridyl]isoquinoline-1,5-diamine dihydroc;1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2);B-Raf inhibitor 1 2HCl;N1-(4-CHLOROPHENYL)-6-METHYL-N5-[3-(9H-PURIN-6-YL)-2-PYRIDINYL]-1,5-ISOQUINOLINEDIAMINE 2HCL |
| CAS号 | 1191385-19-9 |
| 分子式 | C26H21Cl3N8 |
| 分子量 | 551.87 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1191385-19-9.mol |
| 结构式 |  |
B-Raf 抑制剂 1 二盐酸盐 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 粉末 |
B-Raf inhibitor 1 (Compound 13)是一种IIA型Raf抑制剂，与DFG-out构象结合，对B-Raf(WT)，B-Raf(V600E)和C-Raf的ki分别为1 nM，1 nM和0.3 nM。
| Target | Value |
|
C-Raf
(Cell-free assay) | 0.3 nM(Ki) |
|
B-Raf(WT)
(Cell-free assay) | 1 nM(Ki) |
|
B-Raf(V600E)
(Cell-free assay) | 1 nM(Ki) |
B-Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC 50 s of 0.31 and 0.72 μM, respectively. B-Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif. B-Raf inhibitor 1 (Compound 13) additionally exhibits low micromolar inhibition against wild type B-Raf cell lines, which may be due to off-target kinase activities or alternatively to pan-Raf inhibition, including Raf dimers.
安全信息
| 海关编码 | 2933998090 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | S6660 | [N/A] B-Raf inhibitor 1 (Compound 13) dihydrochloride | 1191385-19-9 | 5mg | 1285.95元 |
| 2024/04/30 | S6660 | [N/A] B-Raf inhibitor 1 (Compound 13) dihydrochloride | 1191385-19-9 | 25mg | 5627.35元 |