175139-41-0
| 中文名称 | 175139-41-0 |
|---|---|
| 中文同义词 | 化合物 T15008 |
| 英文名称 | CP 316311 |
| 英文同义词 | CP 316311;Pyridine, 4-(1-ethylpropoxy)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-;3,6-dimethyl-4-pentan-3-yloxy-2-(2,4,6-trimethylphenoxy)pyridine;CP-316 |
| CAS号 | 175139-41-0 |
| 分子式 | C21H29NO2 |
| 分子量 | 327.46 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 175139-41-0.mol |
| 结构式 |  |
175139-41-0 性质
| 熔点 | 72.5-74 °C |
|---|---|
| 沸点 | 413.9±40.0 °C(Predicted) |
| 密度 | 1.007±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 5.63±0.30(Predicted) |
CP 316311 是一种有效的，选择性的 CRF1 receptor 拮抗剂，IC50 值为 6.8 nM。
IC50: 6.8 nM (CRF1 receptor)
CP 316311 fully antagonizes CRF-stimulated adenylate cyclase activity in rat cortex and at human CRF1 receptors endogenously expressed in IMR32 cells with apparent K i values of 7.6 and 8.5 nM, respectively.
CP 316311 (3.2 mg/kg) inhibits 125 I-oCRF binding by >80% in rats. CP 316311 significantly attenuates activation of the hypothalamic−pituitary−adrenal (HPA) axis, with an MED value of 10 mg/kg, p.o. CP 316311 blocks the effects of both the exogenous and endogenous CRF in the CNS. CP 316311 blocks the effects induced by the exogeneous or endogeneous CRF in the brain in rat models.