N-(2,4,6-三甲基苯基)-双环[2.2.1]庚烷-2-甲酰胺
中文名称 | N-(2,4,6-三甲基苯基)-双环[2.2.1]庚烷-2-甲酰胺 |
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中文同义词 | N-(2,4,6-三甲基苯基)-双环[2.2.1]庚烷-2-甲酰胺;N-均三甲基苯基双环[2.2.1]庚烷-2-甲酰胺;化合物ML213;ML213,KV7.2和KV7.4通道开启器 |
英文名称 | ML213 |
英文同义词 | N-(2,4,6-TriMethylphenyl)-bicyclo[2.2.1]heptane-2-carboxaMide;CID 3111211;CID3111211;ML213;ML 213;CID 3111211;CID3111211;CS-2507;ML-213(CID-3111211);Bicyclo[2.2.1]heptane-2-carboxamide, N-(2,4,6-trimethylphenyl)- |
CAS号 | 489402-47-3 |
分子式 | C17H23NO |
分子量 | 257.37 |
EINECS号 | 803-886-4 |
相关类别 | |
Mol文件 | 489402-47-3.mol |
结构式 |
N-(2,4,6-三甲基苯基)-双环[2.2.1]庚烷-2-甲酰胺 性质
沸点 | 398.8±11.0 °C(Predicted) |
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密度 | 1.106±0.06 g/cm3(Predicted) |
储存条件 | Sealed in dry,2-8°C |
溶解度 | DMSO:可溶5mg/mL,澄清(加热) |
酸度系数(pKa) | 14.79±0.70(Predicted) |
形态 | 粉末 |
颜色 | 白色至米色 |
EC50: 230 nM (Kv7.2 channel), 510 nM (Kv7.4 channel)
ML213 (100 nM-30 µM) increases maximal conductance to a peak at 212% ± 27% of control, with an EC 50 of 0.8 ± 0.3 µM. ML213 (10 µM) reduces the deactivation rates of Kv7.4 currents by 4.6-fold in the voltage range from −130 mV to −90 mV. ML213 is a potent and effective activator of homomeric Kv7.5 channels overexpressed in A7r5 cells. ML213 increases maximal conductance of Kv7.5 channels with an EC 50 of 0.7 ± 0.2 µM. ML213 (10 µM) also reduces deactivation rates of Kv7.5 currents by 5.9-fold on average. ML213 produces similar effects on heteromeric Kv7.4/7.5 channels: 204% ± 11% maximal increase in conductance with an EC 50 of 1.1 ± 0.6 µM and a 34.2 ± 3.3 mV maximal negative shift of the activation curve, with an EC 50 of 3.8 ± 1.2 µM. ML213 causes a vasorelaxation in different precontracted rat blood vessels. ML213 (10 μM) also hyperpolarizes mesenteric artery smooth muscle cells. ML213 causes a concentration-dependent shift in the V1/2 for KCNQ2 activation with an EC 50 340 ± 70 nM and a maximal shift of 37.4 mV.
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | S6553 | N-(2,4,6-三甲基苯基)-双环[2.2.1]庚烷-2-甲酰胺 ML213 | 489402-47-3 | 5mg | 620.34元 |
2023/03/20 | S6553 | N-(2,4,6-三甲基苯基)-双环[2.2.1]庚烷-2-甲酰胺 ML213 | 489402-47-3 | 25mg | 2180.36元 |