1-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA
生物活性靶点体外研究体内研究 用途与合成方法 MSDS 1-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA价格(试剂级) 上下游产品信息
| 中文名称 | 1-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA |
|---|---|
| 中文同义词 | 化合物ML297;1-(3,4-二氟苯基)-3-(3-甲基-1-苯基-1H-吡唑-5-基)脲;ML 297,KIR3.1 / 3.2(GIRK1 / 2)通道激活剂 |
| 英文名称 | VU0456810 |
| 英文同义词 | 1-(3,4-Difluorophenyl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea;CID 56642816;ML297;VU0456810;1-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA;ML297, Pubchem: CID 56642816;ML297 (VU0456810);ML 297;ML-297;ML297;VU0456810;VU-0456810;VU 0456810 |
| CAS号 | 1443246-62-5 |
| 分子式 | C17H14F2N4O |
| 分子量 | 328.32 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1443246-62-5.mol |
| 结构式 |  |
1-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA 性质
| 沸点 | 377.8±42.0 °C(Predicted) |
|---|---|
| 密度 | 1.32±0.1 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | DMSO：可溶15mg/mL，澄清 |
| 酸度系数(pKa) | 12.54±0.70(Predicted) |
| 形态 | 白色粉末 |
| 颜色 | 白色至米色 |
| 稳定性 | 自购买之日起，稳定期为 1 年。 其DMSO 或乙醇溶液可在 -20°C 下保存长达 3 个月。 |
ML-297 (VU 0456810, CID 56642816)是一种有效的、选择性的 Kir3.1/3.2 (G protein-coupled inwardly rectifying potassium, GIRK1/2) 通道的激活剂，其对于GIRK1/2和GIRK1/4的EC50值分别为0.16 μM和1.8 μM。ML-297 具有治疗癫痫的潜力。
| Target | Value |
|
GIRK1/2
(Cell-free assay) | 0.16 μM |
|
GIRK1/4
(Cell-free assay) | 1.8 μM |
ML 297 is completely inactive for GIRK
2/3
.
ML297 shows concentration-dependent efficacy in expressing GIRK1/2 cells and with an EC
50
of 162 nM.
ML297 shows a complete inability to modulate the activity of HEK-293 cells expressing GIRK
2
alone and GIRKGIRK
2/3
.
ML297 (60 mg/kg; i.p.) shows a highly significant ability to both prevent convulsions and prevent fatality of the PTZ treatment.
| Animal Model: | 8-10 months old C57/BL6 male mice (approximately 30 g) |
| Dosage: | 60 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Most of the animals neither convulsions nor death. |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-110192 | 1-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA ML 297 | 1443246-62-5 | 5mg | 700元 |
| 2024/04/30 | HY-110192 | 1-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA ML 297 | 1443246-62-5 | 10mM * 1mLin DMSO | 770元 |