- Empagliflozin Intermediate
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- $0.00 / 1Kg/Bag
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2024-08-27
- CAS:915095-94-2
- Min. Order: 2Kg/Bag
- Purity: 99% up, High Density
- Supply Ability: 20 tons
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| (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Basic information | Physical Form Uses |
Product Name: | (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran | Synonyms: | (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan;(S)-3-(4-(2-chloro-5-iodobenzyl)phenoxy)-tetrahydrofuran;(S)-3-(4-(2-chloro-5-fluorobenzyl)phenoxy)-tetrahydrofuran;(3S)-3-{4-[(2-chloro-5-iodophenyl)methyl]phenoxy}oxolane;(3S)-3-[4-(2-chloro-5-iodobenzyl)-phenoxy]-tetrahydrofuran;Furan, 3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-, (3S)-;Empagliflozin Intermediate1;3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan | CAS: | 915095-94-2 | MF: | C17H16ClIO2 | MW: | 414.67 | EINECS: | 619-599-0 | Product Categories: | Empagliflozin;Empagliflozin Intermediate;915095-94-2 | Mol File: | 915095-94-2.mol | ![(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Structure](CAS/20150408/GIF/915095-94-2.gif) |
| (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Chemical Properties |
Boiling point | 476.0±45.0 °C(Predicted) | density | 1.578±0.06 g/cm3 (20 ºC 760 Torr) | storage temp. | 2-8°C(protect from light) | solubility | DMSO, Methanol (Slightly, Sonicated) | form | Solid | color | White to Off-White | InChI | InChI=1S/C17H16ClIO2/c18-17-6-3-14(19)10-13(17)9-12-1-4-15(5-2-12)21-16-7-8-20-11-16/h1-6,10,16H,7-9,11H2/t16-/m0/s1 | InChIKey | YLUHNGIWRCCQMQ-INIZCTEOSA-N | SMILES | O1CC[C@H](OC2=CC=C(CC3=CC(I)=CC=C3Cl)C=C2)C1 | CAS DataBase Reference | 915095-94-2 |
| (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Usage And Synthesis |
Physical Form | Solid | Uses |
(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran(915095-94-2) can be used as reactant/reagent in preparation of C-?aryl D-?glurofuranoside compounds useful as reference compounds in the quality control of gliflozin type medicine.
| Description | (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran is a pharmaceutical intermediate compound that is used in the preparation of empagliflozin. Empagliflozin is an inhibitor of sodium-glucose co-transporter protein-2 (SGLT2), which is used in the treatment of type 2 diabetes. | Preparation | 0.5 mol of raw material and 0.6 mol of aluminum chloride were added to 2 mol of methanol at a temperature of 20° C, and then 0.6 mol of triethylsilane was added to the mixed solution. The mixture was stirred at 25° C for 1 h.The conversion is determined by HPLC analysis. After the reaction is complete, it is extracted and distilled under reduced pressure.Finally, (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan was obtained through purification.
![(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan](/NewsImg/2023-09-21/6383091813460367816902960.jpg) |
| (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Preparation Products And Raw materials |
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