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| FTI-277 Basic information |
Product Name: | FTI-277 | Synonyms: | METHYL[N-[2-PHENYL-4-N-[2(R)-AMINO-3-MERCAPTOPROPYLAMINO] BENZOYL]]-METHIONATE, TFA;FTI-277;N-[4-[2(R)-AMINO-3-MERCAPTOPROPYL]AMINO-2-PHENYLBENZOYL]METHIONINE METHYL ESTER TRIFLUOROACETATE SALT;N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine methyl ester trifluoroacetate salt;N-[[5-[[(2R)-2-Amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-L-methionine methyl ester;FTI-277;FTI277;L-Methionine, N-[[5-[[(2R)-2-amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-, methyl ester | CAS: | 170006-73-2 | MF: | C22H29N3O3S2 | MW: | 447.61 | EINECS: | | Product Categories: | | Mol File: | 170006-73-2.mol | ![FTI-277 Structure](CAS/GIF/170006-73-2.gif) |
| FTI-277 Chemical Properties |
Boiling point | 684.2±55.0 °C(Predicted) | density | 1.222±0.06 g/cm3(Predicted) | storage temp. | −20°C | solubility | H2O: soluble | pka | 9.81±0.10(Predicted) | form | amorphous semi-solid |
Hazard Codes | Xi | Risk Statements | 36/37/38 | Safety Statements | 26-36 | WGK Germany | 3 |
| FTI-277 Usage And Synthesis |
Uses | Farnesyltransferase inhibitor 277 (FTI-277) has been used to:
- inhibit protein farnesylation in breast cell lines.
- in marrow-isolated adult multilineage inducible cells (MIAMI).
- inhibition of farnesyl transferase in CV-1 in Origin with SV40 genes cells (COS-7).
| Biochem/physiol Actions | Farnesyltransferase inhibitor 277 (FTI-277) mediates apoptosis in multiple myeloma and is regarded as a potential therapeutic agent. |
| FTI-277 Preparation Products And Raw materials |
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