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FTI-277 trifluoroacetate salt
Price | $1 |
Package | 1g |
Min. Order: | 1g |
Supply Ability: | 200kg |
Update Time: | 2020-01-10 |
Product Details
Product Name: FTI-277 trifluoroacetate salt | CAS No.: 170006-73-2 |
Min. Order: 1g | Purity: 99% |
Supply Ability: 200kg | Release date: 2020/01/10 |
Mary
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Name
FTI-277 trifluoroacetate salt
Synonym
More Synonyms
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Description
FTI-277 is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling.IC50 value:Target: FTase inhibitorin vitro: Treatment with FTI-277 (20 microM) for 48 h prior to irradiation led to a significant decrease in survival of radioresistant cells expressing the 24-kDa isoform (HeLa 3A) but had no effect on the survival of control cells (HeLa PINA). The radiosensitizing effect of FTI-277 is accompanied by a stimulation of postmitotic cell death in HeLa 3A cells and by a reduction in G(2)/M-phase arrest in both cell types [1]. Treatment of PC-3 cells with GGTI-298 and FTI-277 inhibited migration and invasion in a time- and dose-dependent manner [3].in vivo: FTI-277 treatment prevented increased PTP-1B and PTEN protein expression in burned mice as compared with vehicle alone. In contrast, FTI-277 did not significantly alter protein expression of PTP-1B and PTEN in sham-burned mice [2].
Related Catalog
Signaling Pathways >> Metabolic Enzyme/Protease >> Farnesyl Transferase
Research Areas >> Cancer
References
[1]. Cohen-Jonathan E, et al. The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS. Radiat Res. 1999 Oct;152(4):404-11.
[2]. Nakazawa H, et al. Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle. PLoS One. 2015 Jan 16;10(1):e0116633.
[3]. Virtanen SS, et al. Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells. Cell Biol Int. 2010 Aug;34(8):815-26.
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Molecular Formula
C22H29N3O3S2
Molecular Weight
447.61
PSA
194.85000
LogP
4.84460
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Hazard Codes
Xi: Irritant;
Risk Phrases
R36/37/38
Safety Phrases
S26
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fti-277
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates:
Pharmaceutical intermediates;
OLED intermediates;
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