254435-95-5
| 中文名称 | 254435-95-5 |
|---|---|
| 中文同义词 | 阿拉泊韦;化合物 T14180;ALISPORIVIR游离态 |
| 英文名称 | alisporivir |
| 英文同义词 | alisporivir;alisporivir /DB025/DB-025;Alisporivir (Debio-025);DEB-025;Debio-025;Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl-(2S)-2-aminobutanoyl-N-methyl-D-alanyl-N-ethyl-L-valyl-L-valyl-N-methyl-L-leucyl] |
| CAS号 | 254435-95-5 |
| 分子式 | C63H113N11O12 |
| 分子量 | 1216.66 |
| EINECS号 | |
| 相关类别 | 医药原料;贝尔卡主打 |
| Mol文件 | 254435-95-5.mol |
| 结构式 |  |
254435-95-5 性质
| 沸点 | 1294.2±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.011±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：≥100mg/mL（82.19mM） |
| 酸度系数(pKa) | 13.32±0.70(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
DEB025 binds to CypA, a peptidyl-prolyl cis-trans isomerase which is a crucial cofactor for HCV replication. Alisporivir (Debio-025) represents the prototype of a new class of non-immunosuppressive cyclophilin inhibitors. Alisporivir prevents HCV protein-mediated collapse of the respiration-driven mitochondrial membrane potential. Alisporivir prevents HCV protein-mediated mitochondrial dysfunction outside the context of apoptosis, calcium overload, production of ROS, dysfunction. In cell culture models, low-micromolar doses of alisporivir block SARS-CoV and MERS-CoV replication. Combination treatment with Alisporivir and ICN-1229 increases the anti-MERS-CoV activity in cell culture. Alisporivir pretreatment stimulates antigen presentation by hepatoma target cells, leading to enhancement of antigen-specific CD8+ T cell activation by 40%. Alisporivir induces an increase of MHC-I and beta-2 microglobulin on the surface of several cell lines.
Combination treatment with Alisporivir and ICN-1229 does not protect against SARS-CoV infection in a mouse model.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-12559 | 254435-95-5 Alisporivir | 254435-95-5 | 1mg | 7000元 |
| 2023/03/20 | HY-16757 | 254435-95-5 Trofinetide | 254435-95-5 | 1mg | 1100元 |