254435-95-5
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- CAS号:
- 254435-95-5
- 英文名:
- alisporivir
- 英文别名:
- DEB-025;Debio-025;alisporivir;Alisporivir (Debio-025);alisporivir /DB025/DB-025;Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl-(2S)-2-aminobutanoyl-N-methyl-D-alanyl-N-ethyl-L-valyl-L-valyl-N-methyl-L-leucyl]
- 中文名:
- 254435-95-5
- 中文别名:
- 阿拉泊韦;化合物 T14180;ALISPORIVIR游离态;环[L-丙氨酰-D-丙氨酰-N-甲基-L-亮氨酸-N-甲基-L-亮氨酸-N-甲基-L-缬氨酸-(2S,3R,4R,6E)-3-羟基-4-甲基-2-(甲氨基)-6-辛烯基-(2S)-2-氨基丁酰基-N-甲基-D-丙氨酰-N-乙基-L-缬氨酸-L-缬氨酸-N-甲基-L-亮氨酸
- CBNumber:
- CB12677410
- 分子式:
- C63H113N11O12
- 分子量:
- 1216.66
- MOL File:
- 254435-95-5.mol
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254435-95-5化学性质
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沸点:
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1294.2±65.0 °C(Predicted)
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密度:
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1.011±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : ≥ 100 mg/mL (82.19 mM)
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酸度系数(pKa):
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13.32±0.70(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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254435-95-5性质、用途与生产工艺
Alisporivir (Debio-025) 是亲环蛋白抑制剂，具有高效的抗丙型肝炎病毒 (HCV) 活性的。
DEB025 binds to CypA, a peptidyl-prolyl cis-trans isomerase which is a crucial cofactor for HCV replication. Alisporivir (Debio-025) represents the prototype of a new class of non-immunosuppressive cyclophilin inhibitors. Alisporivir prevents HCV protein-mediated collapse of the respiration-driven mitochondrial membrane potential. Alisporivir prevents HCV protein-mediated mitochondrial dysfunction outside the context of apoptosis, calcium overload, production of ROS, dysfunction. In cell culture models, low-micromolar doses of alisporivir block SARS-CoV and MERS-CoV replication. Combination treatment with Alisporivir and ICN-1229 increases the anti-MERS-CoV activity in cell culture. Alisporivir pretreatment stimulates antigen presentation by hepatoma target cells, leading to enhancement of antigen-specific CD8+ T cell activation by 40%. Alisporivir induces an increase of MHC-I and beta-2 microglobulin on the surface of several cell lines.
Combination treatment with Alisporivir and ICN-1229 does not protect against SARS-CoV infection in a mouse model.
254435-95-5
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-12559 | 254435-95-5
Alisporivir | 254435-95-5 | 1mg | 7000元 |
| 2023/03/20 | HY-16757 | 254435-95-5
Trofinetide | 254435-95-5 | 1mg | 1100元 |
254435-95-5, 254435-95-5 相关搜索:
- 贝尔卡主打
- 医药原料
- 环[L-丙氨酰-D-丙氨酰-N-甲基-L-亮氨酸-N-甲基-L-亮氨酸-N-甲基-L-缬氨酸-(2S,3R,4R,6E)-3-羟基-4-甲基-2-(甲氨基)-6-辛烯基-(2S)-2-氨基丁酰基-N-甲基-D-丙氨酰-N-乙基-L-缬氨酸-L-缬氨酸-N-甲基-L-亮氨酸
- ALISPORIVIR游离态
- 化合物 T14180
- 阿拉泊韦
- 254435-95-5
- Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl-(2S)-2-aminobutanoyl-N-methyl-D-alanyl-N-ethyl-L-valyl-L-valyl-N-methyl-L-leucyl]
- Debio-025
- DEB-025
- Alisporivir (Debio-025)
- alisporivir /DB025/DB-025
- alisporivir