C-GPAP
| 中文名称 | C-GPAP |
|---|---|
| 中文同义词 | CGAMP铵盐;CGAMP 钠盐;CGAMP游离态;2-氨基-9-((2R,3R,3AS,7AR,9R,10R,10AS,14AR)-9-(6-氨基-9H-嘌呤-9-基)-3,5,10,12-四羟基-5,12-DIOXIDOOCTAHYDRO-2H,7H-二呋喃[3,2-D:3',2'-J][1,3,7,9]四氧杂[2,8]二磷酸环十二烯-2-基)-3,9-二氢-6H-嘌呤-6-酮;2-氨基-9-((2R,3R,3AS,7AR,9R,10R,10AS,14AR)-9-(6-氨基-9H-嘌呤-9-基)-3,5,10,12-四羟基-5,12-DIOXIDOOCTAHYDRO-2H,7H-二呋喃[3,2-D:3',2'-J][1,3,7,9]四氧杂[2,8]二磷酸环十二烯-2-基)-3,9-二氢-6H-嘌呤-6-酮;糖蛋白AP;CGAMP 钠盐,STING激动剂 |
| 英文名称 | c-GpAp |
| 英文同义词 | c-GpAp;di-GAMP;di-cGAMP;cGAMP;3'3'-cGAMP;cGAMP (Cyclic GMP-AMP;3''-Guanylic acid, adenylyl-(3''?5'')-, cyclic nucleotide;3',3'-Cyclic guanosine monophosphate-adenosine monophosphate |
| CAS号 | 849214-04-6 |
| 分子式 | C20H24N10O13P2 |
| 分子量 | 674.41 |
| EINECS号 | |
| 相关类别 | 生物活性分子-API;活性分子;干扰素诱导物;对照品;Nucleotides, Bases & Related Reagents, Derivatives |
| Mol文件 | 849214-04-6.mol |
| 结构式 |  |
C-GPAP 性质
| 沸点 | 1159.9±75.0 °C(Predicted) |
|---|---|
| 密度 | 2.61±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 酸度系数(pKa) | 0.96±0.70(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 水溶解性 | Water : 20 mg/mL (29.66 mM) |
3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP)可激活内质网(ER)内源性受体 stimulator of interferon genes (STING) ，从而诱导抗病毒状态和I型IFN的分泌。
| Target | Value |
|
STING
() |
cGAMP promotes the antigen-specific proliferation capacity of spleen cells in mice.
cGAMP directly activates murine and human dendritic cells in vitro.
On stimulation with cGAMP, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF).
cGAMP activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs.
cGAMP promotes the antigen-specific cytokine production by spleen cells of immunized mice.
| Animal Model: | Female C57BL/6 (H-2b) mice 6–8 weeks old |
| Dosage: | 5 µg |
| Administration: | Nostril mucosal adjuvant |
| Result: | Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | S7905 | 3',3'-cGAMP | 10mM (1mL in DMSO) | 9582.3元 | |
| 2024/01/16 | S7905 | C-GPAP 3',3'-cGAMP | 849214-04-6 | 1mg | 5850.11元 |