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| | 2-Hydroxy Atorvastatin Calcium Salt Basic information |
| Product Name: | 2-Hydroxy Atorvastatin Calcium Salt | | Synonyms: | 2-Hydroxy Atorvastatin CalciuM Salt;2-Hydroxy Atorvastatin Sodium;Atorvastatin Impurity K;Atorvastatin impurity 39/Atorvastatin 2-Hydroxy Calcium Salt/ortho-Hydroxy Atorvastatin Calcium Salt/(3R,5R)-7-[3-(2-Hydroxyphenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calcium salt;calcium,(3S,5S)-7-[2-(4-fluorophenyl)-4-[(2-hydroxyphenyl)carbamoyl]-3-phenyl-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate;2-Hydroxy Atorvastatin D5 Calcium SaltQ: What is
2-Hydroxy Atorvastatin D5 Calcium Salt Q: What is the CAS Number of
2-Hydroxy Atorvastatin D5 Calcium Salt Q: What is the storage condition of
2-Hydroxy Atorvastatin D5 Calcium Salt Q: What are the applications of
2-Hydroxy Atorvastatin D5 Calcium Salt;2-Hydroxy Atorvastatin Calcium SaltQ: What is
2-Hydroxy Atorvastatin Calcium Salt Q: What is the CAS Number of
2-Hydroxy Atorvastatin Calcium Salt Q: What is the storage condition of
2-Hydroxy Atorvastatin Calcium Salt Q: What are the applications of
2-Hydroxy Atorvastatin Calcium Salt;inhibit,2-Hydroxy atorvastatin,2Hydroxy atorvastatin calcium salt,Drug Metabolite,Inhibitor,2 Hydroxy atorvastatin calcium salt | | CAS: | 265989-46-6 | | MF: | C33H37CaFN2O6 | | MW: | 616.74 | | EINECS: | | | Product Categories: | 1 | | Mol File: | 265989-46-6.mol |  |
| | 2-Hydroxy Atorvastatin Calcium Salt Chemical Properties |
| Melting point | >166°C (dec.) | | storage temp. | Hygroscopic, Refrigerator, under inert atmosphere | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Yellow | | Stability: | Hygroscopic |
| | 2-Hydroxy Atorvastatin Calcium Salt Usage And Synthesis |
| Chemical Properties | White to Pale Yellow Solid | | Uses | di(2-Hydroxy Atorvastatin) Calcium Salt is a metabolite of Atorvastatin Calcium Salt (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia. | | Biological Activity | 2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt. Atorvastatin is a potent HMG-CoA reductase inhibitor with an IC50 value of 8 nM. It inhibits lipid hydroperoxide formation and copper sulfate-induced thiobarbituric acid reactive substances (TBARS) formation in 1,2-dilinoleoyl-sn-glycero-3-PC (DLPC) vesicles and human LDL, respectively, in a concentration-dependent manner. 2-Hydroxy Atorvastatin reduces cell death induced by oxygen-glucose deprivation (OGD) in primary rat cortical neurons and increases phosphorylation of cAMP-response-element-binding protein (CREB) in GABAergic neurons when used at a concentration of 600 nM following OGD. |
| | 2-Hydroxy Atorvastatin Calcium Salt Preparation Products And Raw materials |
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