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RO-31-7549

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RO-31-7549 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:Bisindolylmaleimide VIII
CAS:125313-65-7
Purity:98.01% Package:1mg;293USD|5mg;722USD|10mg;987USD
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel: +86-057181025280; +8617767106207
Email: sales@molcore.com
Products Intro: Product Name:Bisindolylmaleimide VIII
CAS:125313-65-7
Purity:NLT 98% Remarks:MC514459
Company Name: J & K SCIENTIFIC LTD.  
Tel: 010-82848833 400-666-7788
Email: jkinfo@jkchemical.com
Products Intro: Product Name:BisindolylMaleiMide VIII Acetic Acid Salt
CAS:125313-65-7
Package:100Mg,10Mg
Company Name: Chemsky (shanghai) International Co.,Ltd  
Tel: 021-50135380
Email: shchemsky@sina.com
Products Intro: Product Name:BisindolylMaleiMide VIII
CAS:125313-65-7
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
Company Name: Sigma-Aldrich  
Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Products Intro: Product Name:Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem
CAS:125313-65-7

RO-31-7549 manufacturers
RO-31-7549 Basic information
Product Name:RO-31-7549
Synonyms:BISINDOLYLMALEIMIDE VIII ACETATE;1H-Pyrrole-2,5-dione, 3-(1-(3-aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-;3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;Bisindolylmaleimide VIII;2-[1-3(AMINOPROPYL)INDOL-3-YL]-3(1-METHYL-1H-INDOL-3-YL)MALEIMIDE, ACETATE;RO-31-7549;RO 31-7549 ACETATE SALT;BIDINDOLYLMALEIMIDE VIII, ACETETE
CAS:125313-65-7
MF:C24H22N4O2
MW:398.46
EINECS:
Product Categories:Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Protein Kinase Inhibitors and Activators
Mol File:125313-65-7.mol
RO-31-7549 Structure
RO-31-7549 Chemical Properties
storage temp. −20°C
solubility DMSO: soluble
form Red to reddish-orange solid
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
RO-31-7549 Usage And Synthesis
UsesIt is a potent inhibitor of protein kinase C (PKC) activity.
General DescriptionA cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC50 = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC. Does not inhibit the tyrosine phosphorylation or the activation of phospholipase Cγ1. Exhibits some degree of PKC isozyme specificity (IC50 = 53 nM for PKCα, 195 nM for PKCβI, 163 nM for PKCβII, 213 nM for PKCγ, and 175 nM for PKCε). Inhibits carbachol-evoked noradrenaline release (IC50 = 600 nM).
Biochem/physiol ActionsCell permeable: yes
RO-31-7549 Preparation Products And Raw materials
Tag:RO-31-7549(125313-65-7) Related Product Information
Bisindolylmaleimide V RO 31-7549, IMMOBILIZED RO 31-7549 ACETATE 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione 3-Isopropenyl-1-methyl-1H-pyrrole RO-31-7549