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| 2-Fluoro-5-methoxy-4-nitrobenzoic acid Basic information |
| 2-Fluoro-5-methoxy-4-nitrobenzoic acid Chemical Properties |
Boiling point | 413.0±45.0 °C(Predicted) | density | 1.514±0.06 g/cm3(Predicted) | pka | 2.25±0.13(Predicted) |
| 2-Fluoro-5-methoxy-4-nitrobenzoic acid Usage And Synthesis |
Synthesis | 2-Fluoro-5-methoxy-4-nitrobenzoic acid can be synthesized using various methods such as the Friedel-Crafts acylation reaction, the Suzuki-Miyaura coupling reaction, and the Buchwald-Hartwig amination reaction. The Friedel-Crafts acylation reaction involves the reaction of 2-fluoro-5-methoxy-4-nitrobenzoyl chloride with methanol in the presence of a catalyst such as aluminum chloride. The Suzuki-Miyaura coupling reaction involves the reaction of 2-fluoro-5-methoxy-4-nitrophenylboronic acid with 4-chlorobenzoic acid in the presence of a palladium catalyst. The Buchwald-Hartwig amination reaction involves the reaction of 2-fluoro-5-methoxy-4-nitroiodobenzene with potassium phthalimide in the presence of a palladium catalyst. |
| 2-Fluoro-5-methoxy-4-nitrobenzoic acid Preparation Products And Raw materials |
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