黑色素聚集激素肽
| 中文名称 | 黑色素聚集激素肽 |
|---|---|
| 中文同义词 | 黑色素聚集激酶素(MCH;鲑鱼黑色素聚集激素;黑色素聚集激素肽;黑素浓集素 |
| 英文名称 | MELANIN CONCENTRATING HORMONE, SALMON |
| 英文同义词 | MELANIN CONCENTRATING HORMONE;MELANIN CONCENTRATING HORMONE, SALMON;MCH (SALMON);ASP-THR-MET-ARG-CYS-MET-VAL-GLY-ARG-VAL-TYR-ARG-PRO-CYS-TRP-GLU-VAL;ASP-THR-MET-ARG-CYS-MET-VAL-GLY-ARG-VAL-TYR-ARG-PRO-CYS-TRP-GLU-VAL [DISULFIDE BRIDGE: 5-14];H-ASP-THR-MET-ARG-CYS-MET-VAL-GLY-ARG-VAL-TYR-ARG-PRO-CYS-TRP-GLU-VAL-OH;ASP-THR-MET-ARG-CYS-MET-VAL-GLY-ARG-VAL-TYR-ARG-PRO-CYS-TRP-GLU-VAL: DTMRCMVGRVYRPCWEV DISULFIDE BRIDGE CYS5-CYS14;Asp-Thr-Met-Arg-c[Cys-Met-Val-Gly-Arg-Val-Tyr-Arg-Pro-Cys]-Trp-Glu-Val |
| CAS号 | 87218-84-6 |
| 分子式 | C89H139N27O24S4 |
| 分子量 | 2099.5 |
| EINECS号 | |
| 相关类别 | 细胞生物学;标准品;目录多肽;Peptide;Hormones;Neuropeptides;Obesity Research |
| Mol文件 | 87218-84-6.mol |
| 结构式 |  |
黑色素聚集激素肽 性质
| 密度 | 1.52±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | −20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
SLC-1/GPR24, MCHR2
An orphan G protein-coupled receptor (SLC-1/GPR24) has been identified as a receptor for MCH (MCHR1). MCHR2 has higher protein sequence homology to MCHR1 than any other G protein-coupled receptor. MCHR2 is specifically activated by nanomolar concentrations of MCH, binds to MCH with high affinity, and signals through Gq protein.
Melanin Concentrating Hormone stimulates appetite. Continuous infusion of Melanin Concentrating Hormone into the ventricular system increases food intake for 7-8 days. Intracerebroventricular infusion of Melanin Concentrating Hormone (10 μg/day) causes a slight but significant increase in body weight in mice maintained on the regular diet. Chronic stimulation of the brain Melanin Concentrating Hormone system could cause obesity in mice.
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| 提供商 | 语言 |
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英文
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