- 4-Hydroxythiobenzamide
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- $16.00 / 25ASSAYS
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2024-08-23
- CAS:25984-63-8
- Min. Order: 1ASSAYS
- Purity: 99%
- Supply Ability: 100mt
- 4-Hydroxythiobenzamide
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- $0.00 / 1kg
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2024-08-22
- CAS:25984-63-8
- Min. Order: 1kg
- Purity: 98%min
- Supply Ability: 1000kg
- 4-HYDROXYTHIOBENZAMIDE
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- $1.90 / 1KG
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2024-08-13
- CAS:25984-63-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 ton
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| | 4-Hydroxythiobenzamide Basic information | | Uses |
| | 4-Hydroxythiobenzamide Chemical Properties |
| Melting point | 181-185℃ | | Boiling point | 320.4±44.0 °C(Predicted) | | density | 1.338±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 9.24±0.26(Predicted) | | color | Light Yellow | | InChI | InChI=1S/C7H7NOS/c8-7(10)5-1-3-6(9)4-2-5/h1-4,9H,(H2,8,10) | | InChIKey | VDTNKXSVUGXUOJ-UHFFFAOYSA-N | | SMILES | C1(C(N)=S)=CC=C(O)C=C1 | | CAS DataBase Reference | 25984-63-8(CAS DataBase Reference) |
| | 4-Hydroxythiobenzamide Usage And Synthesis |
| Uses |
4-Hydroxythiobenzamide(25984-63-8) is used in the synthesis of PPARα agonists used in increasing HDLc levels. Also used in the synthesis of potent CDK5 inhibitors in the treatment of Alzheimer’s disease.
| | Chemical Properties | 4-Hydroxythiobenzamide has an appearance ranging from light orange to yellow to green, powder to crystalline, melting point 192 °C, soluble in methanol. | | Uses | febuxostat intermediate | | Uses | 4-Hydroxythiobenzamide is used in the synthesis of PPARα agonists used in increasing HDLc levels. Also used in the synthesis of potent CDK5 inhibitors in the treatment of Alzheimer’s disease. | | Synthesis |
4-Hydroxythiobenzamide is an important intermediate of Febuxostat, a new anti-gout drug. A patent discloses a method for preparing p-hydroxythiobenzamide. Specifically, a certain amount of water, p-cyanophenol, sodium hydrosulfide, and secondary amine are mixed evenly. At a specific temperature, an organic weak acid is added dropwise. After the reaction is completed, the mixture is filtered, and the filter cake is dried to obtain 4-Hydroxythiobenzamide.
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| | 4-Hydroxythiobenzamide Preparation Products And Raw materials |
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