RP70676
中文名称 | RP70676 |
---|---|
中文同义词 | RP 70676游离态;化合物 T12767;化合物RP 70676 |
英文名称 | RP 70676 |
英文同义词 | RP 70676;1H-Pyrazole, 1-[5-[(4,5-diphenyl-1H-imidazol-2-yl)thio]pentyl]-3,5-dimethyl-;RP 70676,RP-70676,Diacylglycerol acyltransferase,mono- acylglycerol acyltransferase,acyl-CoA:cholesterol acyltransferase,inhibit,RP70676,Inhibitor,Diglyceride acyltransferase,Acyltransferase |
CAS号 | 136609-26-2 |
分子式 | C25H28N4S |
分子量 | 416.58 |
EINECS号 | |
相关类别 | |
Mol文件 | 136609-26-2.mol |
结构式 |
RP70676 性质
沸点 | 605.9±57.0 °C(Predicted) |
---|---|
密度 | 1.16±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 可溶于DMSO(少许)、甲醇(少许) |
形态 | 固体 |
酸度系数(pKa) | 11.80±0.10(Predicted) |
颜色 | 白色至类白色 |
IC50: 25 nM (Rat ACAT), 44 nM (Rabbit ACAT)
RP 70676 is a potent inhibitor of rabbit arterial ACAT (IC 50 = 40 nM) and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC 50 values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues the mean IC 50 is 44 nM. In whole cell P388D, murine macrophages the compound has an IC 50 of 540 nM.
RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels in NZW rabbits.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/11/08 | HY-101576 | RP 70676 | 1 mg | 1300元 | |
2024/11/08 | HY-101576 | 136609-26-2 RP 70676 | 136609-26-2 | 5 mg | 2800元 |