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Product Name:11-hydroxy-5(Z),8(Z),12(E),14(Z)-Eicosatetraenoic acid
CAS:73804-65-6
Purity:98+% Package:100ug
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Alfa Chemistry
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| Products Intro: |
Product Name:11-hydroxy-5(Z),8(Z),12(E),14(Z)-eicosatetraenoic acid
CAS:73804-65-6
Purity:98%+ Package:1g;10g;100g;1KG;5KG
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| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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400-9205774 |
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| Products Intro: |
Product Name:(±)11-HETE
CAS:73804-65-6
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| | (+/-)11-HETE Basic information |
| Product Name: | (+/-)11-HETE | | Synonyms: | (+/-)11-HETE;(+/-)11-HYDROXY-5Z,8Z,12E,14Z-EICOSATETRAENOIC ACID;11-Hydroxyicosa-5,8,12,14-tetraenoic acid;11-hydroxy-5(Z),8(Z),12(E),14(Z)-ETA | | CAS: | 73804-65-6 | | MF: | C20H32O3 | | MW: | 320.47 | | EINECS: | | | Product Categories: | | | Mol File: | 73804-65-6.mol |  |
| | (+/-)11-HETE Chemical Properties |
| storage temp. | Store at -20°C | | solubility | 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml |
| | (+/-)11-HETE Usage And Synthesis |
| Description | (±)11-HETE is an oxylipin formed non-enzymatically from arachidonic acid .1,2 Levels of (±)11-HETE are increased in an in vitro model of lipid peroxidation induced by ferrous ammonium sulfate (FAS) in rat brain homogenates.3 Levels are also increased in rat liver in an in vivo model of lipid peroxidation induced by carbon tetrachloride (CCl4). It has been found in skin extracts from individuals with psoriasis and in atherosclerotic plaques.4,5 | | Uses | 11-HETE (11-Hydroxy-5,8,12,14-eicosatetraenoic acid) is the activator for cytochrome P450. 11-HETE upregulates the mRNA expressions of CYP1B1, CYP1A1, CYP4A11, CYP4F11, and CYP4F2, induces cell hypertrophy in RL-14 cell, and exhibits potential to be used in cardiovascular diseases[1]. | | References | 1. Powell, W.S., and Rokach, J. Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid Biochim. Biophys. Acta 1851(4),340-355(2014).
2. Derogis, P.B.M.C., Chaves-Filho, A.B., and Miyamoto, S. Characterization of hydroxy and hydroperoxy polyunsaturated fatty acids by mass spectrometry Bioactive lipids in health and disease ,21-38(2019).
3. Guido, D.M., McKenna, R., and Mathews, W.R. Quantitation of hydroperoxy-eicosatetraenoic acids and hydroxy-eicosatetraenoic acids as indicators of lipid peroxidation using gas chromatography-mass spectrometry Anal. Biochem. 209(1),123-129(1993).
4. Camp, R.D.R., Mallet, A.I., Woollard, P.M., et al. The identification of hydroxy fatty acids in psoriatic skin Prostaglandins 26(3),431-447(1983).
5. Waddington, E., Sienuarine, K., Puddey, I., et al. Identification and quantitation of unique fatty acid oxidation products in human atherosclerotic plaque using high-performance liquid chromatography Anal. Biochem. 292(2),234-244(2001). |
| | (+/-)11-HETE Preparation Products And Raw materials |
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