2-氨基-2-去甲菠烷羧酸
| 中文名称 | 2-氨基-2-去甲菠烷羧酸 |
|---|---|
| 中文同义词 | 2-氨基-2-去甲菠烷羧酸;2-氨基-2-二甲基降莰烷;2-氨基双环[2.2.1]庚烷-2-羧酸;2-氨基二环[2.2.1]庚烷-2-羧酸;2-氨基-2-去甲冰片羧酸 |
| 英文名称 | 2-AMINO-2-NORBORNANECARBOXYLIC ACID |
| 英文同义词 | 2-AMINO-2-NORBORNANECARBOXYLIC ACID;2-AMINOBICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID;BCH;2-AMINO-2-NORBORNANECARBOXYLIC ACID, 98% , MIXTURE OF ISOMERS;2-Amino-2-carboxy-bicyclo-2,2,1-heptane;2-Aminonorbornane-2-carboxylic acid;B-Bch;Bicyclo(2.2.1)heptane-2-carboxylic acid, 2-amino- |
| CAS号 | 20448-79-7 |
| 分子式 | C8H13NO2 |
| 分子量 | 155.19 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 20448-79-7.mol |
| 结构式 |  |
2-氨基-2-去甲菠烷羧酸 性质
| 熔点 | >300 °C(lit.) |
|---|---|
| 沸点 | 295.5±23.0 °C(Predicted) |
| 密度 | 1.256±0.06 g/cm3(Predicted) |
| 储存条件 | Keep in dark place,Sealed in dry,Room Temperature |
| 溶解度 | 酸水溶液（微溶） |
| 形态 | 固体 |
| 酸度系数(pKa) | 2.58±0.20(Predicted) |
| 颜色 | 白色 |
| 水溶解性 | Soluble to 100 mM in water |
| CAS 数据库 | 20448-79-7(CAS DataBase Reference) |
| Target | Value |
|
LAT1
() |
LAT1-IN-1 (1-100 mM; 3 days; KYSE30 and KYSE150 esophageal cancer cells) treatment suppresses cell proliferation in a dose-dependent manner.
LAT1-IN-1 (30 mM; 24 and 48 hours; KYSE30 and KYSE150 cells) treatment significantly increases cell population in the G0/G1 phase in both KYSE30 and KYSE150 cells, indicating that LAT1-IN-1 induces cell cycle arrest at G1 phase.
LAT1-IN-1 (30 mM; 0-24 hours; KYSE30 and KYSE150 cells) treatment decreases phosphorylation of 4E-BP1 and p70S6K at 30 minutes and the decrease is continued for 24 hours. The amount of mTOR, 4E-BP1, and p70S6K proteins is slightly decreased.
Cell Proliferation Assay
| Cell Line: | KYSE30 and KYSE150 esophageal cancer cells |
| Concentration: | 1 mM, 3 mM, 5 mM, 10 mM, 20 mM, 30 mM, 40 mM, 50 mM, or 100 mM |
| Incubation Time: | 3 days |
| Result: | Cell proliferation was suppressed in a dose-dependent manner. |
Cell Cycle Analysis
| Cell Line: | KYSE30 and KYSE150 cells |
| Concentration: | 30 mM |
| Incubation Time: | 24 and 48 hours |
| Result: | Cell cycle arrest. |
Western Blot Analysis
| Cell Line: | KYSE30 and KYSE150 cells |
| Concentration: | 30 mM |
| Incubation Time: | 0 hour, 0.5 hour, 1 hour, 3 hours, 6 hours, 24 hours |
| Result: | Phosphorylation of 4E-BP1 and p70S6K was decreased. The amount of mTOR, 4E-BP1, and p70S6K proteins was slightly decreased. |
LAT1-IN-1 (200 mg/kg; intravenous injection; daily; for 14 days; male BALB/c nude mice) treatment significantly delays tumor growth and decreases glucose metabolism, indicating that LAT1 inhibition potentially suppresses esophageal cancer growth in vivo.
| Animal Model: | Male BALB/c nude mice (5-week-old) with KYSE150 cells |
| Dosage: | 200 mg/kg |
| Administration: | Intravenous injection; daily; for 14 days |
| Result: | Significantly delayed tumor growth and decreased glucose metabolism. |
安全信息
| WGK Germany | 3 |
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| 提供商 | 语言 |
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-108540 | 2-氨基-2-去甲菠烷羧酸 LAT1-IN-1 | 20448-79-7 | 50mg | 600元 |
| 2024/04/30 | HY-108540 | 2-氨基-2-去甲菠烷羧酸 LAT1-IN-1 | 20448-79-7 | 10mM * 1mLin Water | 660元 |