化合物TRPM4-IN-1
| 中文名称 | 化合物TRPM4-IN-1 |
|---|---|
| 中文同义词 | 化合物TRPM4-IN-1;4-氯-2-(2-(2-氯苯氧基)乙酰氨基)苯甲酸;CBA,TRPM4阻滞剂 |
| 英文名称 | 4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid |
| 英文同义词 | 4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid;4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid;Benzoic acid, 4-chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]-;TRPM4-IN-5;TRPM4-IN-1;TRPM4 inhibitor 5;CBA (TRPM4-IN-5);TRP Channel,Transient receptor potential channels,non-selective,TRPM4IN1,diseases,TRPM4,inhibit,Inhibitor,TRPM-4-IN-1,TRPM4 IN 1,cancer,cation,cardiac,channel,prostate,calcium-activated |
| CAS号 | 351424-20-9 |
| 分子式 | C15H11Cl2NO4 |
| 分子量 | 340.16 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 351424-20-9.mol |
| 结构式 |  |
化合物TRPM4-IN-1 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 颜色 | 白色至黄色 |
TRPM4-IN-1 (CBA) 是一种有效的、选择性的阳离子通道 TRPM4 抑制剂，其 IC50 为 1.5 μM。TRPM4-IN-1 可用于心脏病和前列腺癌的研究。
TRPM4-IN-1 (compound 5) is a potent and selective inhibitor of TRPM4 current in TRPM4 overexpressed HEK293 cells.
TRPM4-IN-1 reversibly blocks endogenous TRPM4 currents in LNCaP (prostate cancer) cells.
TRPM4-IN-1 (50 μM; Overnight) restores functional expression of A432T, a loss‐of‐expression TRPM4 variant.
Western Blot Analysis
| Cell Line: | HEK293 cells |
| Concentration: | 50 μM |
| Incubation Time: | Overnight |
| Result: | Partial rescued the total and surface expression of A432T. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-122605 | TRPM4-IN-1 | 5 mg | 437元 | |
| 2024/11/08 | HY-122605 | 化合物TRPM4-IN-1 TRPM4-IN-1 | 351424-20-9 | 10mg | 700元 |