| Company Name: |
Hangzhou Sage Chemical Co., Ltd.
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+86057186818502 13588463833 |
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info@sagechem.com |
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Product Name:Ethanol, 2-[[7-Methyl-6-[(phenylMethyl)aMino]-7H-purin-2-yl]aMino]-
CAS:101622-50-8
Purity:98% Package:1g;5g;100g;Bulk
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| Company Name: |
BOC Sciences
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Product Name:Iso-olomoucine
CAS:101622-50-8
Purity:≥98% Remarks:Iso-olomoucine is an inactive stereoisomer of olomoucine, a cyclin-dependent kinase (CDK) inhibitor. Olomoucine competitively inhibits the cell cycle regulating p34cdc2/cyclin B, p33cdk2/cyclin A and
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:Iso-Olomoucine
CAS:101622-50-8
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| | 6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE Basic information |
| | 6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE Chemical Properties |
| density | 1.36 | | storage temp. | Store at -20°C | | solubility | ≤0.3mg/ml in ethanol;15mg/ml in DMSO;15mg/ml in dimethyl formamide | | form | Off-white solid. |
| | 6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE Usage And Synthesis |
| Uses | Iso-olomoucine is a potent and selective inhibitor of cdc2, cdk and orther cyclin related kinases. | | Definition | ChEBI: 2-[[7-methyl-6-[(phenylmethyl)amino]-2-purinyl]amino]ethanol is a thiopurine. | | Biological Activity | iso-olomoucine is an inactive stereoisomer of the cdk5 inhibitor olomoucine.cyclin-dependent kinases (cdks) are reported to be key regulators of cell cycle progression whose function/dysfunction has been implicated in cancer, human neurodegenerative diseases, as well as the response of addictive drugs through alteration of postsynaptic dopamine receptor signaling. | | in vitro | in a previous study, rat dorsal striatal synaptosomes were incubation with the cdk5 inhibitors roscovitine, olomoucine, and gw8510 or the inactive congener iso-olomoucine, which led to a rapid, concentration-dependent inhibition of specific [3h]da uptake. however, roscovitine was the only inhibitor that did not decrease [3h]2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane binding to dstr dats. roscovitine-induced inhibition of dstr [3h]da uptake was demonstrated by decreased maximal uptake velocity, without a change in cell-surface dat levels. moreover, roscovitine did not enhance [3h]da release mediated by either dat reverse-transport. instead, roscovitine could enhance spontaneous [3h]da outflow and inhibit dat-mediated [3h]da reaccumulation into dstr slices. additionally, in a cdk5-independent manner, iso-olomoucine was able to rapidly inhibit dopamine transporter activity in rat dorsal striatal synaptosomes with a potency similar to that of olomoucine (ic50 ~37 μm) [1] | | IC 50 | ≥ 1 mm for cdk5 | | references | [1] price, d. a.,sorkin, a. and zahniser, n.r. cyclin-dependent kinase 5 inhibitors: inhibition of dopamine transporter activity. molecular pharmacology 76(4), 812-823 (2009). |
| | 6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE Preparation Products And Raw materials |
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