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| | CLORGYLINE HYDROCHLORIDE Basic information |
| Product Name: | CLORGYLINE HYDROCHLORIDE | | Synonyms: | CLORGYLINE HYDROCHLORIDE;N-METHYL-N-PROPARGYL-3-(2,4-DICHLOROPHENOXY)-PROPYLAMINE HYDROCHLORIDE;3-(2,4-dichlorophenoxy)-n-methyl-n-propargyl-propylaminhydrochloride;n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propyn-1-aminhydrochloride;n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propynylaminhydrochloride;N-methyl-N-propargyl-3-(2,4-*dichlorophenoxy)prop;N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-2-propynylamine hydrochloride;N-METHYL-N-PROPARGYL-3-(2,4-*DICHLOROPHE NOXY)PROPYL | | CAS: | 17780-75-5 | | MF: | C13H16Cl3NO | | MW: | 308.63 | | EINECS: | 241-760-5 | | Product Categories: | | | Mol File: | 17780-75-5.mol |  |
| | CLORGYLINE HYDROCHLORIDE Chemical Properties |
| storage temp. | 2-8°C | | solubility | ≥17.65 mg/mL in DMSO; ≥18.2 mg/mL in EtOH; ≥24.8 mg/mL in H2O | | form | A crystalline solid | | color | White to off-white |
| Hazard Codes | Xn | | Risk Statements | 20/21/22 | | Safety Statements | 36 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS | UI0675000 | | HazardClass | 6.1(b) | | PackingGroup | III |
| | CLORGYLINE HYDROCHLORIDE Usage And Synthesis |
| Description | Clorgyline is a potent monoamine oxidase (MAO) inhibitor that preferentially targets MAO-A over MAO-B (Kis = 0.054 and 58 μM, respectively). This inhibition is irreversible. Clorgyline is without effect on serotonin receptors, but it does inhibit the sigma receptor σ1 on Jurkat human T lymphocyte cells (IC50 = 31 nM). As MAO-A preferentially oxidizes serotonin, selective MAO-A inhibitors have applications in ameliorating depression and anxiety. | | Uses | Antidepressant;Monoamine oxidase A inhibitor | | Uses | N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride has been used as a monoamine oxidase A (MAO-A) inhibitor:
- in MAO-A biochemical assay
- to study its effects on the transit of serotonin (5-HT) in the human placenta explants
- to study its effects on human prostate cancer cells
| | Biochem/physiol Actions | MAO-A inhibitor. | | references | [1]. abdelhafez om, amin km, ali hi, et al. synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase a inhibitors. j med chem. 2012 dec 13;55(23):10424-36.
[2]. mazouz f, gueddari s, burstein c, et al. 5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3h)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type b inhibitors. j med chem. 1993 apr 30;36(9):1157-67.
[3]. garcia-miralles m, ooi j, ferrari bardile c, et al. treatment with the mao-a inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of huntington disease. exp neurol. 2016 apr;278:4-10. |
| | CLORGYLINE HYDROCHLORIDE Preparation Products And Raw materials |
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