Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA
| 中文名称 | Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA |
|---|---|
| 中文同义词 | 神经肽Α-CGRP (RAT) |
| 英文名称 | Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA |
| 英文同义词 | Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA |
| CAS号 | |
| 分子式 | C???H???N??O??S?.C?HF?O? |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | 目录多肽 |
| Mol文件 | Mol File |
| 结构式 |
Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA 性质
CRLR.
Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA) belongs to the calcitonin family of neuropeptides which also includes adrenomedullin, amylin, calcitonin, intermedin and calcitonin receptor-stimulating peptide. Calcitonin Gene Related Peptide (CGRP) has two isoforms (αCGRP and βCGRP), and acts through calcitonin receptor-like receptor (CRLR). Calcitonin Gene Related Peptide (CGRP) plays a key role in migraine pathophysiology and is associated with activation of the trigeminovascular system. CGRP prossibly acts postjunctionally in these areas putatively involved in primary headaches.
Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA) is a potent inducer of oedema in rat orofacial tissue. CGRP (100 μL; 8-33 pM) induces a rapidly developing (5-15 min) and long-lasting (6 h), dose-dependent oedema in the rat cheek. CGRP induces a smaller oedematogenic effect in the rat hind paw also blocked by the CGRP antagonist. CGRP (16 pM) potentiates the oedema induced by co-injected substance P (3.7 nM).