P物质
中文名称 | P物质 |
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中文同义词 | P物质;P物质?, >98%;物质 P;多肽物质P;神经肽H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2;ANTI-SUBSTANCE P ANTIBODY-P物质抗体;三乙酸多肽物质P;P物质 酰胺、NEUROKININ P AMIDE |
英文名称 | SUBSTANCE P |
英文同义词 | ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2;H2N-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET;H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2;SUBSTANCE P, F & D VERSION OF S6883*ACET ATE;(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide;SUBSTANCE P (HUMAN, BOVINE, RAT, MOUSE);SUBSTANCE P BOVINE;SUBSTANCE P, [D-ARG1, D-PRO2, D-TRP7,9, LEU11] |
CAS号 | 33507-63-0 |
分子式 | C63H98N18O13S |
分子量 | 1347.63 |
EINECS号 | 251-545-8 |
相关类别 | 人检测系列;氨基酸及其衍生物;生化试剂;生物化学品;标准品;Peptide;TPI;Tachykinin receptor;Peptide Receptors |
Mol文件 | 33507-63-0.mol |
结构式 | ![]() |
P物质 性质
熔点 | 148 °C |
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密度 | 1.42±0.1 g/cm3(Predicted) |
储存条件 | −20°C |
溶解度 | H2O:1 mg/mL |
酸度系数(pKa) | 13.26±0.46(Predicted) |
形态 | 粉末 |
颜色 | 白色 |
水溶解性 | Soluble in water, DMSO, and Acetic Acid. |
序列 | H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 |
InChIKey | ADNPLDHMAVUMIW-UHFFFAOYSA-N |
Human Endogenous Metabolite
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The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells.
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
安全信息
WGK Germany | 3 |
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F | 3-10-21 |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | XW3350763002 | P物质 | 33507-63-0 | 10MG | 1635元 |
2024/04/30 | XW3350763003 | P物质 | 33507-63-0 | 25MG | 2528元 |