DMG-PEG2000
| 中文名称 | DMG-PEG2000 |
|---|---|
| 中文同义词 | DMG-PEG2000阳离子脂质体;DMG-PEG2000长循环脂质体;ONPATTRO磷脂DMG-PEG2000;1,2-二肉豆蔻酰基-SN-甘油-3-甲氧基聚乙二醇;1,2-二肉豆蔻酰-RAC-甘油-3-甲氧基聚乙二醇2000;1,2-二肉豆蔻酰-RAC-甘油-3-甲氧基聚乙二醇;聚(氧-1,2-乙二基), Α-[2,3-双[(1-氧代十四烷基)氧基]丙基]-Ω-甲氧基-;化合物DMG-PEG2000 |
| 英文名称 | DMG-PEG 2000 |
| 英文同义词 | DMG-PEG 2000;1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000;1,?2-?Dimyristoyl-?sn-?glycero-?3-?methoxypolyethylene glycol;Polyethylene glycol [PEG] 2000 dimyristoyl glycerol [DMG];Methoxypoly(ethylene glycol) dimyristoyl glycerol;DMG-mPEG2000;Poly(oxy-1,2-ethanediyl), α-[2,3-bis[(1-oxotetradecyl)oxy]propyl]-ω-methoxy-;1,2-Dimyristoyl-sn-glycero-3-methoxypolyethylene glycol 2000 |
| CAS号 | 160743-62-4 |
| 分子式 | |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | 蔗糖（供注射用）;阳离子脂质;新冠疫苗辅料;DMG系列产品 |
| Mol文件 | Mol File |
| 结构式 |
DMG-PEG2000 性质
| 储存条件 | -20°C, sealed storage, away from moisture and light |
|---|---|
| 溶解度 | 二甲基亚砜：100 mg/ml |
| 形态 | 结晶固体 |
| 颜色 | 白色至浅黄色 |
NP-3 (0.05-1.6 mg/mL; 24 hours) does not decrease the cytotoxicity of cells in 293T, HepG2, A549, and HeLa cell lines, but the DPPC and DMG-PEG coated nanoparticles reduce cell cytotoxicity. In addition, the transfection efficiency of DPPC/DMG-PEG/(lPEI/DNA) nanoparticles (NP-3) in 293 cells is improved, and the maximum transfection efficiency (∼76% eGFP positive cells) is observed.
NP-3 (oral administration; 150 μg DNA per mouse; single dose) at 12, 24, and 36 h postadministration, luciferin substrate is intraperitoneally injected to verify its permeability. NP-3 group maintains high luciferase expression in the liver, lung, and intestine areas 12-24 h post-treatment.Additionally, NP-3 exhibits 1.5 times higher signal intensity than that of NP-1 or NP-2 group from 12 to 24 h postoral administration.