1821143-79-6
中文名称 | 1821143-79-6 |
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中文同义词 | 化合物 T11065 |
英文名称 | DMU2105 |
英文同义词 | 2-Propen-1-one, 3-(2-naphthalenyl)-1-(3-pyridinyl)-, (2E)-;(2E)-3-(naphthalen-2-yl)-1-(pyridin-3-yl)prop-2-en-1-one |
CAS号 | 1821143-79-6 |
分子式 | C18H13NO |
分子量 | 259.3 |
EINECS号 | |
相关类别 | API |
Mol文件 | 1821143-79-6.mol |
结构式 |
1821143-79-6 性质
沸点 | 463.7±37.0 °C(Predicted) |
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密度 | 1.194±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
形态 | 固体 |
酸度系数(pKa) | 2.89±0.10(Predicted) |
颜色 | 浅黄至黄色 |
CYP1B1 10 nM (IC 50 ) |
CYP1A1 742 nM (IC 50 ) |
DMU2105 (Compound 7k) shows 74 and 120-fold selectivity for CYP1B1 over CYP1A1 and CYP1A2. In the presence of DMU2105 however, the EC 50 goes down to 1 μM indicating that the cells have suffered from toxicity which may have been mediated by CYP1B1 inhibition. Un-transfected cells (HEK293: pcDNA3.1), when treated with cisplatin and DMU2105 (10×IC 50 ) do not show any perceptible decrease of cisplatin EC 50 (8.5 μM ± 0.9).