245747-71-1
中文名称 | 245747-71-1 |
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中文同义词 | 化合物 T12218;NFAT转录因子调节剂-1;N-(4-(5-(二氟甲氧基)-3-(三氟甲基)-1H-吡唑-1-基)苯基)-3-氟异烟酰胺 |
英文名称 | NFAT Transcription Factor Regulator |
英文同义词 | NFAT Transcription Factor Regulator;NFAT Transcription Factor Regulator-1;4-Pyridinecarboxamide, N-[4-[5-(difluoromethoxy)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-;NFAT Transcription Factor Regulator 1,NFAT Transcription Factor Regulator1;N-(4-(5-(Difluoromethoxy)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-3-fluoroisonicotinamide |
CAS号 | 245747-71-1 |
分子式 | C17H10F6N4O2 |
分子量 | 416.28 |
EINECS号 | |
相关类别 | |
Mol文件 | 245747-71-1.mol |
结构式 | ![]() |
245747-71-1 性质
沸点 | 408.4±45.0 °C(Predicted) |
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密度 | 1.53±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | DMSO:≥ 150 mg/mL (360.33 mM);水:< 0.1 mg/mL(不溶) |
形态 | 固体 |
酸度系数(pKa) | 9.85±0.70(Predicted) |
颜色 | 浅黄至黄色 |
IL-2 182 nM (IC 50 ) |
NFAT Transcription Factor Regulator-1 (compound example 19) inhibits IL-2 synthesis with an IC 50 of 182 nM. NFAT Transcription Factor Regulator-1 inhibits human and rat PBMC proliferation with IC 50 s of 82 and 146 nM, respectively. NFAT Transcription Factor Regulator-1 is able to inhibit IL-4 and IL-5 production in human T-cell lines with similar potency to its effects on IL-2 release.
NFAT Transcription Factor Regulator-1 is found to have an inhibitory potency approximately 10-fold better than that of cyclosporine. Comparable inhibitory effects on T-cell IL-2 production are obtained with NFAT Transcription Factor Regulator-1 and cyclosporine at doses of 3.0 and 30 mg/kg, po, respectively. The efficacies achieved in monkeys in vivo for blocking T-cell cytokine production suggest that NFAT Transcription Factor Regulator-1 has potential similar to that of cyclosporine for use in transplantation.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-112778 | NFAT Transcription Factor Regulator-1 | 1 mg | 666元 | |
2024/08/19 | HY-112778 | 245747-71-1 NFAT Transcription Factor Regulator-1 | 245747-71-1 | 5mg | 1750元 |