245747-71-1
| 中文名称 | 245747-71-1 |
|---|---|
| 中文同义词 | 化合物 T12218;NFAT转录因子调节剂-1;N-(4-(5-(二氟甲氧基)-3-(三氟甲基)-1H-吡唑-1-基)苯基)-3-氟异烟酰胺 |
| 英文名称 | NFAT Transcription Factor Regulator |
| 英文同义词 | NFAT Transcription Factor Regulator;NFAT Transcription Factor Regulator-1;4-Pyridinecarboxamide, N-[4-[5-(difluoromethoxy)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-;NFAT Transcription Factor Regulator 1,NFAT Transcription Factor Regulator1;N-(4-(5-(Difluoromethoxy)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-3-fluoroisonicotinamide |
| CAS号 | 245747-71-1 |
| 分子式 | C17H10F6N4O2 |
| 分子量 | 416.28 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 245747-71-1.mol |
| 结构式 |  |
245747-71-1 性质
| 沸点 | 408.4±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.53±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：≥ 150 mg/mL (360.33 mM)；水：< 0.1 mg/mL（不溶） |
| 形态 | 固体 |
| 酸度系数(pKa) | 9.85±0.70(Predicted) |
| 颜色 | 浅黄至黄色 |
|
IL-2 182 nM (IC 50 ) |
NFAT Transcription Factor Regulator-1 (compound example 19) inhibits IL-2 synthesis with an IC 50 of 182 nM. NFAT Transcription Factor Regulator-1 inhibits human and rat PBMC proliferation with IC 50 s of 82 and 146 nM, respectively. NFAT Transcription Factor Regulator-1 is able to inhibit IL-4 and IL-5 production in human T-cell lines with similar potency to its effects on IL-2 release.
NFAT Transcription Factor Regulator-1 is found to have an inhibitory potency approximately 10-fold better than that of cyclosporine. Comparable inhibitory effects on T-cell IL-2 production are obtained with NFAT Transcription Factor Regulator-1 and cyclosporine at doses of 3.0 and 30 mg/kg, po, respectively. The efficacies achieved in monkeys in vivo for blocking T-cell cytokine production suggest that NFAT Transcription Factor Regulator-1 has potential similar to that of cyclosporine for use in transplantation.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-112778 | NFAT Transcription Factor Regulator-1 | 1 mg | 666元 | |
| 2024/08/19 | HY-112778 | 245747-71-1 NFAT Transcription Factor Regulator-1 | 245747-71-1 | 5mg | 1750元 |