Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
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Tel: |
15076683720 |
Email: |
klq@cw-bio.com |
Products Intro: |
Product Name:NFAT transcription factor regulator 1 CAS:245747-71-1 Purity:大于98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
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Company Name: |
Fan De(Beijing) Biotechnology Co., Ltd.
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Tel: |
15911056312 |
Email: |
liming@bio-fount.com |
Products Intro: |
Product Name:NFAT Transcription Factor Regulator CAS:245747-71-1 Purity:97.0% Package:5mg
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| NFAT Transcription Factor Regulator Basic information |
Product Name: | NFAT Transcription Factor Regulator | Synonyms: | NFAT Transcription Factor Regulator;NFAT Transcription Factor Regulator-1;4-Pyridinecarboxamide, N-[4-[5-(difluoromethoxy)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-;NFAT Transcription Factor Regulator 1,NFAT Transcription Factor Regulator1;N-(4-(5-(Difluoromethoxy)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-3-fluoroisonicotinamide | CAS: | 245747-71-1 | MF: | C17H10F6N4O2 | MW: | 416.28 | EINECS: | | Product Categories: | | Mol File: | 245747-71-1.mol | ![NFAT Transcription Factor Regulator Structure](CAS/20200611/GIF/245747-71-1.gif) |
| NFAT Transcription Factor Regulator Chemical Properties |
Boiling point | 408.4±45.0 °C(Predicted) | density | 1.53±0.1 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMSO : ≥ 150 mg/mL (360.33 mM);Water : < 0.1 mg/mL (insoluble) | form | Solid | pka | 9.85±0.70(Predicted) | color | Light yellow to yellow |
| NFAT Transcription Factor Regulator Usage And Synthesis |
Biological Activity | NFAT Transcription Factor Regulator-1 is an inhibitor of IL-2 synthesis with IC50 of 182 nM. | in vitro | NFAT Transcription Factor Regulator-1 (compound example 19) inhibits IL-2 synthesis with an IC 50 of 182 nM. NFAT Transcription Factor Regulator-1 inhibits human and rat PBMC proliferation with IC 50 s of 82 and 146 nM, respectively. NFAT Transcription Factor Regulator-1 is able to inhibit IL-4 and IL-5 production in human T-cell lines with similar potency to its effects on IL -2 release. | target | IL-2 < span> 182 nM (IC 50 ) | |
| NFAT Transcription Factor Regulator Preparation Products And Raw materials |
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