西维美林
中文名称 | 西维美林 |
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中文同义词 | 西维美林;盐酸西维美林杂质;顺式-2-甲基-1'-氮杂螺[[1,3]氧硫杂戊烷-5,3'-双环[2.2.2]辛烷 |
英文名称 | CEVIMELINE, HYDROCHLORIDE SALT |
英文同义词 | CevimelineHClSalt;(+/-)-cis-2-Methylspiro[1,3-oxathiolane-5,3quinuclidine;Spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane], 2'-methyl-, (2'R,3R)-rel-;Spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane], 2'-methyl-, cis-;2-methyspiro(1,3-oxathiolane-5,3)quinuclidine;AF-102B;Evoxac;SNI-2011 |
CAS号 | 107233-08-9 |
分子式 | C10H17NOS |
分子量 | 199.31 |
EINECS号 | |
相关类别 | 神经信号;Heterocycles;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals |
Mol文件 | 107233-08-9.mol |
结构式 | ![]() |
西维美林 性质
熔点 | 195-197°C |
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沸点 | 308.5±42.0 °C(Predicted) |
密度 | 1.19 |
储存条件 | Sealed in dry,Store in freezer, under -20°C |
溶解度 | 溶于二甲基亚砜 |
形态 | 粉末 |
酸度系数(pKa) | 9.51±0.40(Predicted) |
CAS 数据库 | 107233-08-9 |
Muscarinic M1 and M3 receptor
In digested parotid cells, Cevimeline (0.1-100 μM) increases the intracellular Ca 2+ concentration.
Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg.
Animal Model: | Male Wistar rats (8-week-old) injected with angiotensin-II |
Dosage: | 0.008 mg/kg, 0.016 mg/kg |
Administration: | Intraperitoneal injection |
Result: | Showed slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2023/03/20 | HY-70020 | 西维美林 Cevimeline | 107233-08-9 | 5 mg | 3000元 |
2023/03/20 | HY-70020 | 西维美林 Cevimeline | 107233-08-9 | 10mg | 5000元 |