| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:PhenaMil Methanesulfonate Salt
CAS:1161-94-0
Package:100Mg,25Mg,5Mg
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Phenamil
CAS:1161-94-0
Purity:solid Package:5mg, 25mg, 100mg Remarks:P203
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| | PHENAMIL METHANESULFONATE Basic information |
| | PHENAMIL METHANESULFONATE Chemical Properties |
| storage temp. | 2-8°C | | solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble2.5mg/mL | | form | solid | | color | yellow | | CAS DataBase Reference | 1161-94-0 |
| | PHENAMIL METHANESULFONATE Usage And Synthesis |
| Chemical Properties | off-white to yellow solid | | Uses | Phenamil methanesulfonate salt has been used:
- to stimulate adipocyte differentiation in 3T3 cells
- to test its effect on lateral flagella expression in Vibrio shilonii
- in nanoparticle preparation to test its effect on osteo/odontoblastic differentiation
| | Uses | Phenamil Methanesulfonate Salt induced differentiation and peroxisome proliferator-activator receptor γ expression through ETS variant 4 in mouse preadipocyte | | General Description | Phenamil, a derivative of amiloride is an inhibitor of sodium channels including acid sensing ion channel (ASIC) and epithelial sodium channels (ENaC). | | Biochem/physiol Actions | Phenamil is an inducer of peroxisome proliferator-activated receptor γ (PPARγ) and inhibits diamine oxidase. By favoring tribbles homolog 3 (Trb3) expression, phenamil holds therapeutic potential to treat pulmonary artery hypertension (PAH) and idiopathic PAH. It is also a bone morphogenetic protein (BMP) activator, which favors osteogenesis and odontogenesis of stem cells. | | storage | Store at +4°C |
| | PHENAMIL METHANESULFONATE Preparation Products And Raw materials |
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