HYMENIALDISINE ANALOGUE #1 基本信息
中文名称 | HYMENIALDISINE ANALOGUE #1 |
---|---|
中文同义词 | |
英文名称 | HYMENIALDISINE ANALOGUE #1 |
英文同义词 | HYMENIALDISINE ANALOGUE #1;5-(2-Amino-5-oxo-1,5-dihydroimidazol-4-ylidene)-3,4,5,10-tetrahydro-2H-azepino[3,4-b]indol-1-one;5-(2-Amino-5-oxo-1,5-dihydroimidazol-4-ylidene)-3,4,5,10-tetrahydro-2H-azepino[3,4-β]indol-1-one;Azepino[3,4-b]indol-1(2H)-one, 5-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-3,4,5,10-tetrahydro- |
CAS号 | 693222-51-4 |
分子式 | C15H13N5O2 |
分子量 | 295.3 |
EINECS号 | |
相关类别 | Protein Kinase Inhibitors and Activators;Tyrosine Kinase Inhibitors |
Mol文件 | 693222-51-4.mol |
结构式 |
HYMENIALDISINE ANALOGUE #1 性质
密度 | 1.73±0.1 g/cm3(Predicted) |
---|---|
储存条件 | -20°C Freezer |
溶解度 | 二甲基亚砜(微溶) |
形态 | 固体 |
酸度系数(pKa) | 14.41±0.20(Predicted) |
颜色 | 浅黄色至厚黄色 |
CAS 数据库 | 693222-51-4 |
用途
The indole derivative of Hymenialdisine, a potent inhibitor of a variety of kinases including MEK-1, GSK-3β, and CKI. It also exhibits inhibition of the G2 cell cycle checkpoint at the micromolar con centrations. This compound exhibits very potent inhibition of Chk2 activity in the low nanomolar range (IC50=8nM). Exhibits an increased selectivity for the checkpoint kinases over natural Hymeniald isine.