| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:ATPA;(RS)-2-AMino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoicacid
CAS:140158-50-5
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Product Name: | ATPA | | Synonyms: | (R,S)-ATPA;(RS)-A-AMINO-3-HYDROXY-5-TERT-BUTYL-4-ISOXAZOLEPROPIONIC ACID;(R,S)-ALPHA-AMINO-3-HYDROXY-5-T-BUTYL-4-ISOXAZOLEPROPIONIC ACID;(RS)-ALPHA-AMINO-3-HYDROXY-5-TERT-BUTYL-4-ISOXAZOLEPROPIONIC ACID;(RS)-2-AMINO-3-(3-HYDROXY-5-TERT-BUTYLISOXAZOL-4-YL)PROPANOIC ACID;ATPA;alpha-amino-3-hydroxy-5-tert-butyl-4-isoxazolepropionate;ATP synthase α chain | | CAS: | 140158-50-5 | | MF: | C10H16N2O4 | | MW: | 228.24 | | EINECS: | | | Product Categories: | | | Mol File: | 140158-50-5.mol |  |
| density | 1.263±0.06 g/cm3(Predicted) | | storage temp. | Desiccate at +4°C | | solubility | DMSO: 10 mg/mL | | pka | 2.15±0.10(Predicted) | | form | solid | | color | white |
| Uses | (R,S)-ATPA is a selective and potent GluR5 kainate receptor agonist (1,2). It inhibits GluK2 kainate receptor-JNK3 protein pathway by activating GABA type A receptor in rat after cerebral ischemia-reperfusion injury (3). (R,S)-ATPA is a neuroprotective agent. | | Definition | ChEBI: 2-amino-3-(5-tert-butyl-3-oxo-4-isoxazolyl)propanoic acid is an alpha-amino acid. | | Biological Activity | A selective and potent GluR5 kainate receptor agonist (K i = 4.3 nM), inactive at GluR6 (K i > 1 mM) and only weakly active at AMPA receptors (GluR1-4) and the kainate receptors KA-2 and GluR7 (K i values of 6 - 14 μ M). Also available as part of the Kainate Receptor Tocriset™ . | | storage | Desiccate at +4°C |
| | ATPA Preparation Products And Raw materials |
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