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| AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2 Basic information |
| AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2 Chemical Properties |
density | 1.39±0.1 g/cm3(Predicted) | storage temp. | -15°C | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | form | Powder | pka | 9.82±0.15(Predicted) |
| AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2 Usage And Synthesis |
Biological Activity | Ac-RYYRIK-NH2 is a potent ORL1 partial agonist as an endogenous ligand of ORL1 in CHO cells (Kd=1.5 nM). Ac-RYYRIK-NH2 is a specific antagonist of G protein activation and competitively antagonizes noc/OFQ-stimulated [35S]-GTPgS-binding G protein in rat meninges and brain sections. | in vivo | Ac-RYYRIK-NH2 (intracerebroventricularly (icv) inhibits spontaneous locomotor activity in mice with an ID 50 of 0.07 nmol. Co-administration of noc/OFQ and Ac-RYYRIK-NH2 | target | Kd: 1.5 nM (ORL1 transfected in CHO cells) |
| AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2 Preparation Products And Raw materials |
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