| Company Name: |
Changzhou Hopschain Chemical Co.,Ltd.
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| Tel: |
0519-85528066 13775048983 |
| Email: |
sales@hopschem.com |
| Products Intro: |
Product Name:2-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]acetic acid
CAS:53808-88-1
Purity:95+% Package:100mg;250mg;500mg;1g;2.5g;5g;10g
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| Company Name: |
Guangzhou Younan Technology Co., Ltd
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| Tel: |
020-82000279 18988968278 |
| Email: |
sales@ubiochem.com |
| Products Intro: |
Product Name:Lonazolac
CAS:53808-88-1
Purity:98% Package:5mg;10mg;50mg;100mg
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:Lonazolac
CAS:53808-88-1
Purity:95.00% Package:1mg/RMB 198;5mg/RMB 431;10mg/RMB 646
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| | lonazolac Basic information |
| Product Name: | lonazolac | | Synonyms: | lonazolac;LONAZOLAC CALCIUM;3-(4-Chlorophenyl)-1-phenyl-1H-pyrazole-4-acetic acid;2-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]acetic acid;1H-Pyrazole-4-acetic acid, 3-(4-chlorophenyl)-1-phenyl-;anti-inflammatory,antirheumatic,non-acidic,Inhibitor,inhibit,Lonazolac | | CAS: | 53808-88-1 | | MF: | C17H13ClN2O2 | | MW: | 312.755 | | EINECS: | 2587915 | | Product Categories: | | | Mol File: | 53808-88-1.mol |  |
| | lonazolac Chemical Properties |
| Melting point | 150-151° | | pka | 4.3(at 25℃) |
| Toxicity | LD50 in male mice, rats (mg/kg): 195, 165 i.v. (Riedel) |
| | lonazolac Usage And Synthesis |
| Originator | Irriten,Tosse,W. Germany,1981 | | Definition | ChEBI: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 3-(4-chlorophenyl)-1-phenylpyrazol-4-yl group. | | Manufacturing Process | 17.6 g 1-phenyl-3-(p-chlorophenyl)-pyrazol-4-acetonitrile and 180 ml 25%
aqueous hydrochloric acid were mixed and heated to the boiling temperature
under reflux for 6 hours. To the mixture was then added dropwise
concentrated aqueous sodium hydroxide until the pH of the mixture reached a
value in the range from 3 to 5. The free pyrazol-4-acetic acid precipitated
thereby was filtered off, redissolved in dilute aqueous sodium hydroxide, the
solution cleared by treatment with activated carbon, and the pyrazol-4-acetic
acid precipitated by acidifying the solution by the addition of dilute mineral
acid, sulfuric acid. The filtered acid was crystallized from a mixture of ethanol
and water. 17.1 g 1-phenyl-3-(p-chlorophenyl)pyrazol-4-acetic acid, melting at
148°C to 150°C, were obtained, representing a yield of 91%. | | Therapeutic Function | Antiinflammatory |
| | lonazolac Preparation Products And Raw materials |
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