盐酸吐根酚碱
| 中文名称 | 盐酸吐根酚碱 |
|---|---|
| 中文同义词 | 吐根酚碱盐酸盐 EP标准品;6-异喹啉,1-[(2S,3R,11BS)-3-乙基-1,3,4,6,7,11B-六羟基-9,10-二甲氧基-2H-苯并[A]喹硫莱胺-2-YL]甲基]-1,2,3,4-四氢-7-甲氧基-,盐酸盐(1:2),(1R)-;吐根酚碱盐酸盐(盐酸吐根酚碱);(1R)-1-[[(2S,3R,11BS)-3-乙基-1,3,4,6,7,11B-六氢-9,10-二甲氧基-2H-苯并[A]喹嗪-2-基]甲基]-1,2,3,4-四氢-7-甲氧基-6-异喹啉醇二盐酸盐;吐根酚碱盐酸盐 EP |
| 英文名称 | cephaeline hydrochloride |
| 英文同义词 | cephaelin hydrochloride;Cephaeline dihydrochloride;(1R)-1-[[(2S,3R,11bS)-3-Ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizin-2-yl]methyl]-1,2,3,4-tetrahydro-7-methoxy-6-isoquinolinol hydrochloride;NSC 32944;Cephaeline HCl salt;(-)-CEPHAELINE DIHYDROCHLORIDE;Cephaeline hydrochloride CRS;Cephaeline DiHCl |
| CAS号 | 5853-29-2 |
| 分子式 | C28H39ClN2O4 |
| 分子量 | 503.08 |
| EINECS号 | 227-463-3 |
| 相关类别 | 对照品-中药对照品;可定制;分析试剂标准品;对照品;杂质对照品;中药对照品 |
| Mol文件 | 5853-29-2.mol |
| 结构式 |  |
盐酸吐根酚碱 性质
| 储存条件 | 4°C, protect from light |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
Cephaeline dihydrochloride 是选择性的 CYP2D6 抑制剂，IC50 为 121 μM。
IC50: 121 μM (CYP2D6)
Ki: 54 μM (CYP2D6)
CYP2D6 reveals the highest metabolic activity for the generation of 9-O-demethylEmetine, whereas this enzyme also shows a significant metabolic activity for the generation of Cephaeline. The IC 50 s of Cephaeline against CYP2C9, CYP2D6 and CYP3A4 is over 1000, 121 and 1000 μM, respectively. Further experiments are performed to determine inhibition constants (K i ) for Cephaeline on the CYP2D6 and CYP3A4 activities Graphic analysis of Dixon plots at various Cephaeline concentrations for each of the two CYP enzyme assays yield K i s of 54 and 355 μM for CYP2D6 and CYP3A4, respectively.
化学性质
类白至黄色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于吐根，安哥拉八角枫。用途
盐酸吐根酚碱能杀灭溶织阿米巴滋养体，有毒。类别
有毒物质毒性分级
高毒急性毒性
腹腔-大鼠 LD50: 10 毫克/公斤; 口服-小鼠 LD50: 74.97 毫克/公斤可燃性危险特性
热分解排出有毒氮氧化物, 氯化氢烟雾储运特性
库房低温通风干燥; 与食品原料分开存放灭火剂
水,二氧化碳, 泡沫, 干粉安全信息
| 危险品运输编号 | 1544 |
|---|---|
| 危险等级 | 6.1(b) |
| 包装类别 | III |
| 毒性 | LD50 oral in mouse: 74970ug/kg |