| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Email: |
inquiries@lgmpharma.com |
| Products Intro: |
Product Name:Ranolazine
CAS:142387-99-3
Purity:Typically NLT 98%
|
| Company Name: |
Jai Radhe Sales
|
| Tel: |
+(91)-(79)-26431096/65255722 |
| Email: |
info@jairadhesales.com |
| Products Intro: |
Product Name:RANOLAZINE
CAS:142387-99-3
Purity:99% Package:GM/KG/TON
|
| Company Name: |
Cangzhou Enke Pharma-tech Co., Ltd.
|
| Tel: |
0317-5296180 15533709196 |
| Email: |
sale@enkepharma.com |
| Products Intro: |
Product Name:Ranolazine
CAS:142387-99-3
Purity:99%化工级 沧州恩科医药科技，大量现货，优势产品，欢迎询价下单，随时为您服务！ Package:1公斤;2公斤;3公斤
|
|
| | Ranolazine Basic information |
| | Ranolazine Chemical Properties |
| storage temp. | RT | | solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml). | | form | solid | | color | White | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| | Ranolazine Usage And Synthesis |
| Description | Ranolazine (142387-99-3) is an FDA-approved drug used for the treatment of chronic angina. It inhibits the late inward sodium current in heart muscle leading to decreased intracellular calcium levels.1?Ranolazine blocks Nav 1.4, 1.5, 1.7 and 1.8 (IC50‘s = 2.42, 6.22, 1.72(10.33), 21.53 μM respectively. | | Uses | Ranolazine is for the treatment of chronic angina. It should be used in combination with amlodipine, beta-blockers or nitrates. | | Definition | ChEBI: N-(2,6-dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamide is an aromatic amide obtained by formal condensation of the carboxy group of 2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetic acid with the amino group of 2,6-dimethylaniline. It is a monocarboxylic acid amide, an aromatic amide, a N-alkylpiperazine, a secondary alcohol and a monomethoxybenzene. | | References | 1) Belardinelli?et al., (2006),?Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine; Heart,?92?iv6
2) Wang?et al. (2008),?State- and Use-Dependent Block of Muscle Nav1.4 and Neuronal Nav1.7 Voltage-Gated Na+-Channel Isoforms by Ranolazine; Mol. Pharmacol.?73?940
3) Rajamani?et al., (2008),?Block of tetrodotoxin-sensitive, Na(V)1.7 and tetrodotoxin-resistant, Na(V)1.8, Na+ channels by ranolazine; Channels(Austin)?2?449 |
| | Ranolazine Preparation Products And Raw materials |
|