123482-23-5
中文名称 | 123482-23-5 |
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中文同义词 | 扎托司琼马来酸盐;化合物 T17285 |
英文名称 | Zatosetron Maleate |
英文同义词 | Zatosetron Maleate;5-Chloro-2,3-dihydro-2,2-dimethyl-N-[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octane-3α-yl]benzofuran-7-carboxamide·maleic acid;LY 277359 maleate |
CAS号 | 123482-23-5 |
分子式 | C23H29ClN2O6 |
分子量 | 464.93916 |
EINECS号 | |
相关类别 | |
Mol文件 | 123482-23-5.mol |
结构式 |
123482-23-5 性质
熔点 | 184-186 °C |
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储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
5-HT 3 Receptor
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Acute administration of 0.1 (n=21) and 0.3 (n=5) mg/kg Zatosetron maleate (Zatosetron) in male rats, but not 0.01, 0.05, 1.0 or 10 mg/kg (n=5, 3, 6 and 4, respectively) Zatosetron maleate or saline (n=5), leads to a significant reduction in the number of spontaneously active A10 dopamine cells. The number of spontaneously active A10 dopamine cells is not significantly different from 30 to 60 min post i.p. Zatosetron maleate (0.1 mg/kg) administration, shows a significant decrease by 60 to 90 min (0.65±0.11, P=0.03, n=5), a larger decrease by 90 to120 min (0.53±0.08, P=0.004, n=5) and remains at this significantly decreased level from 2 to 3 h (0.50+0.05, P=0.0004, n=5). Single-unit recordings show that Zatosetron maleate inhibits the activity of A10 dopamine cells following i.v. administration (ED 50 =0.12 mg/kg, n=8). Chronic administration of 0.1 mg/kg (n=16) Zatosetron maleate, but not 0.01, 1.0 or 10 mg/kg (n=4, 8 and 7, respectively) Zatosetron maleate or saline (n=5), leads to a significant reduction in the number of spontaneously active A10 dopamine cells.