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| | (R)-(-)-alpha-Methoxyphenylacetic acid Basic information |
| | (R)-(-)-alpha-Methoxyphenylacetic acid Chemical Properties |
| Melting point | 66-68 °C(lit.) | | Boiling point | 164-166°C 18mm | | alpha | -160.4 º (C=1, MEOH) | | density | 1.1708 (rough estimate) | | refractive index | -147 ° (C=0.5, EtOH) | | Fp | 164-166°C/18mm | | storage temp. | 2-8°C | | solubility | Chloroform, Ethanol, Methanol | | form | Fine Crystalline Powder or Needles | | pka | 3.10±0.10(Predicted) | | color | White | | optical activity | [α]20/D -150±3°, c = 0.5% in ethanol | | BRN | 3589257 | | CAS DataBase Reference | 3966-32-3(CAS DataBase Reference) | | NIST Chemistry Reference | (R)-(-)-«alpha»-methoxyphenylacetic acid(3966-32-3) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HS Code | 29189900 |
| | (R)-(-)-alpha-Methoxyphenylacetic acid Usage And Synthesis |
| Chemical Properties | white fine crystalline powder or needles | | Uses | (R)-(-)-α-Methoxyphenylacetic Acid is a useful synthetic intermediate. It is used as a reactant in the synthesis of dopamine receptor agonists. It can also be used to prepare hydroxytriamides as potent γ-secretase inhibitors. | | General Description | (R)-(?)-α-Methoxyphenylacetic acid is a chiral derivatizating agent, which is employed for derivatizing enantiomers into diastereoisomers. | | Purification Methods | Purify the acids by recrystallising from *C6H6/pet ether (b 80-100o). [Neilson & Peters J Chem Soc 1519 1962, Weizmann et al. J Am Chem Soc 70 1153 1948, Pirie & Smith J Chem Soc 338 1932, NMR: Dale & Mosher J Am Chem Soc 9 5 512 1973, for resolution: Roy & Deslongchamps Can J Chem 63 651 1985, Trost et al. J Am Chem Soc 1 0 8 4974 1986.] The racemic mixture has m 72o, b 121-122o/0.4mm, 165o/18mm (from pet ether) [Braun et al. Chem Ber 6 3 2847 1930]. [Beilstein 10 IV 566.] |
| | (R)-(-)-alpha-Methoxyphenylacetic acid Preparation Products And Raw materials |
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