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4-isothiocyanato-2-(trifluoroMethyl)benzonitrile

4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Suppliers list
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Products Intro: Product Name:3-Fluoro-4-methylphenylisothiocyanate
CAS:143782-23-4
Purity:99%
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Products Intro: Product Name:4-isothiocyanato-2-(trifluoroMethyl)benzonitrile
CAS:143782-23-4
Purity:99.0min Package:1KG;0USD|100KG;0USD|1000KG;0USD|10000KG;0USD
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Products Intro: Product Name:Enzalutamide intermediate
CAS:143782-23-4
Purity:0.99 Package:5KG;1KG:5KG;10KG
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Products Intro: Product Name:4-Isothiocyanato-2-(trifluoromethyl)benzonitrile
CAS:143782-23-4
Purity:99% Package:1kg ;10kg;25kg
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Products Intro: Product Name:4-isothiocyanato-2-(trifluoroMethyl)benzonitrile
CAS:143782-23-4
Purity:0.99 Package:5KG;1KG Remarks:99% HPLC

4-isothiocyanato-2-(trifluoroMethyl)benzonitrile manufacturers

4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Basic information
Product Name: 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile
Synonyms:Benzonitrile,4-isothiocyanato-2-(trifluoroMethyl)-;3. 4-Isothiocyanato-2-(trifluoroMethyl)benzonitrile;4-cyano-3-trifluoromenthylphenylisothiocyanate;4-Isothiocyanato-2-(trifluoromethyl)benzonitrile,Enzalutamide intermediate;4-isothiocyananto-2-(trifluoromethyl) benzonitrile;4-ISOTHIOCYANATO-2-(TRIFLUOROMETHYL)BENZONITRILE/4-CYANO-3-TRIFLUOROMETHYLPHENYLISOTHIOCYANATE /CAS NO: 143782-23-4;Enzalutamide intermediate;Enzalutamide Impurity Z
CAS:143782-23-4
MF:C9H3F3N2S
MW:228.19
EINECS:1592732-453-0
Product Categories:143782-23-4
Mol File:143782-23-4.mol
	4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Structure
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Chemical Properties
Melting point 39.0 to 43.0 °C
Boiling point 331℃
density 1.31
Fp 154℃
solubility Chloroform (Sparingly), DMSO (Sparingly), Methanol (Slightly)
form powder to lump
color White to Yellow to Green
Stability:Hygroscopic, Moisture sensitive
InChIInChI=1S/C9H3F3N2S/c10-9(11,12)8-3-7(14-5-15)2-1-6(8)4-13/h1-3H
InChIKeyTYXKOMAQTWRDCR-UHFFFAOYSA-N
SMILESC(#N)C1=CC=C(N=C=S)C=C1C(F)(F)F
CAS DataBase Reference143782-23-4
Safety Information
HS Code 2929100090
MSDS Information
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Usage And Synthesis
Uses4-Cyano-3-trifluoromethylphenylisothiocyanate is an reagent used in the synthesis of thioxoimidazolidinones as potential anti-prostate cancer agents.
Uses4-Isothiocyanoyl-2-(trifluoromethyl)benzonitrile is a reagent used to synthesize thioimidazolinone compounds and is a potential anti-prostate cancer drug. It is also used as an intermediate of enzalutamide.
SynthesisSynthesis_143782-23-4
4-Amino-2-trifluoromethylbenzonitrile, (2.23 g, 12 mmol) was added portionwise over15 minutes into the well-stirred heterogeneous mixture of thiophosgene (1 ml, 13 mmol) in water (22 ml) at room temperature. Stirring was continued for an additional 1 h. The reaction medium was extracted with chloroform (3 x 15 ml). The combined organic phase was dried over MgSO4 and evaporated to dryness under reduced pressure to yield desired product, 4-isothiocyanato-2-trifluoromethylbenzonitrile, (Ia), as brownish solid and was used as such for the next step (2.72 g, 11.9 mmol, 99%).
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Preparation Products And Raw materials
Preparation Products4-(3-(4-hydroxyphenyl)-4,4-diMethyl-5-oxo-2-thioxoiMidazolidin-1-yl)-2-(trifluoroMethyl)benzonitrile-->Enzalutamide
Tag: 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile(143782-23-4) Related Product Information
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