| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Asocainol
CAS:77400-65-8
Package:2.5Mg,25Mg
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| Company Name: |
Chemsky (shanghai) International Co.,Ltd
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| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:Asocainol
CAS:77400-65-8
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
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| Company Name: |
Hubei huizepu Pharmaceutical Technology Co., Ltd
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| Tel: |
027-19371-3712 19371278702 |
| Email: |
n17762444226@163.com |
| Products Intro: |
Product Name:5H-Dibenz[d,f]azonin-1-ol,6,7,8,9-tetrahydro-2,12-dimethoxy-7-methyl-6-(2-phenylethyl)-
CAS:77400-65-8
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| | Asocainol Basic information |
| Product Name: | Asocainol | | Synonyms: | Asocainol;6,7,8,9-Tetrahydro-2,12-dimethoxy-7-methyl-6-(2-phenylethyl)-5H-dibenz[d,f]azonin-1-ol;Go-4704;Goe-4704;5H-Dibenz[d,f]azonin-1-ol, 6,7,8,9-tetrahydro-2,12-dimethoxy-7-methyl-6-(2-phenylethyl)- | | CAS: | 77400-65-8 | | MF: | C27H31NO3 | | MW: | 417.54 | | EINECS: | | | Product Categories: | Aromatics;Heterocycles;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Pharmaceuticals | | Mol File: | 77400-65-8.mol |  |
| | Asocainol Chemical Properties |
| | Asocainol Usage And Synthesis |
| Originator | Asocainol,ZYF Pharm | | Uses | Asocainol (ASOC) belongs to class I antiarrhythmic drugs, i.e., those that exert their action at the level of sodium channels of the myocardial cell membrane. | | Uses | Labelled Asocainol | | Manufacturing Process | A solution of a Grignard reagent is prepared from 5.5 g (0.23 mol) activated
magnesium turnings and 41.5 g (0.24 mol) phenethyl bromide in 200 ml
anhydrous diethyl ether. To this is added dropwise, at 35-40°C, a solution of
31.5 g (0.1 mol) thebaine in 0.4 liters dry benzene. After heating under reflux
for 2 hours, the reaction mixture is decomposed with a solution of 48 g
ammonium chloride in 200 ml water. The usual working up, after conversion
of the base into the hydrochloride by means of hydrogen chloride in ethyl
acetate, gives 7.3 g (21% of theory) (+/-)-2,12-dimethoxy-1-hydroxy-7-
methyl-6-phenethyl-5,6,8,9-tetrahydro-7H-dibenz[d,f]azonine hydrochloride,
melting point 227.6°C, after recrystallization from propan-2-ol. | | Therapeutic Function | Antiarrhythmic |
| | Asocainol Preparation Products And Raw materials |
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