达罗地平
| 中文名称 | 达罗地平 |
|---|---|
| 中文同义词 | 达罗地平;化合物 T15053 |
| 英文名称 | Darodipine |
| 英文同义词 | Darodipine;4-(Benzofurazan-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid diethyl ester;PY-108063;PY-108068;PY-108-068;Darodipine(PY-108068);3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester;PY108068,Ca channels,PY 108068,Calcium Channel,Darodipine,Ca2+ channels,Inhibitor,inhibit |
| CAS号 | 72803-02-2 |
| 分子式 | C19H21N3O5 |
| 分子量 | 371.39 |
| EINECS号 | |
| 相关类别 | 生物化工 |
| Mol文件 | 72803-02-2.mol |
| 结构式 |  |
达罗地平 性质
| 熔点 | 148-151°C |
|---|---|
| 储存条件 | Refrigerator |
| 溶解度 | 可溶于氯仿（少许）、DMSO（少许）、甲醇（少许） |
| 形态 | 固体 |
| 颜色 | 淡黄色至浅黄色 |
Darodipine (PY 108-068, PY-108068) 是有效地钙离子通道 (calcium chanel) 拮抗剂。
Treatment with darodipine increases the number and the average length of alkaline phosphatase-reactive capillaries and reduces the intercapillary distance and the diameter of cerebral capillaries in old rats. The pericapillary microrenvironment of the Ammon’s horn is the most sensitive to treatment with darodipine. Darodipine may reduce neuronal cytoskeletal changes occurring in aging and in neurodegenerative disorders. A 6-month treatment (from the 18th to the 24th month of life) with an oral daily dose of 10 mg/kg of darodipine restores in part the expression of 200 kDa-NF subunit immunoreactivity in the cerebellar cortex.