氟齐胺
| 中文名称 | 氟齐胺 |
|---|---|
| 中文同义词 | 氟齐胺;氟泽酰胺;化合物 T15302 |
| 英文名称 | Fluzinamide |
| 英文同义词 | Fluzinamide;3-[3-(Trifluoromethyl)phenoxy]-1-(methylcarbamoyl)azetidine;AHR-8559;1-Azetidinecarboxamide, N-methyl-3-[3-(trifluoromethyl)phenoxy]- |
| CAS号 | 76263-13-3 |
| 分子式 | C12H13F3N2O2 |
| 分子量 | 274.24 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 76263-13-3.mol |
| 结构式 |  |
氟齐胺 性质
| 沸点 | 415.7±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.337±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 14.24±0.40(Predicted) |
Fluzinamide, an antiepileptic agent effective against partial seizures, is metabolized extensively in mice, rats and dogs.The anticonvulsant properties of Fluzinamide (AHR-8559) are evaluated in the kindled amygdaloid seizure model in rats. Fluzinamide significantly attenuates afterdischarge durations and the severity of the accompanying convulsive responses in previously kindled rats at doses that does not cause sedation or ataxia. After acute intraperitoneal injections, the maximum anticonvulsant effectiveness against suprathreshold (400 μA) stimulation is seen at 30 min. Fluzinamide (10-80 mg/kg i.p.) is also evaluated in kindled rats using threshold (20 μA increments) seizures. Low doses of Fluzinamide significantly elevate seizure threshold and reduce both elicited after discharge durations and seizure severity. When administered daily during kindling acquisition, Fluzinamide (20 and 40 mg/kg i.p.) significantly increases the number of trials necessary to complete kindling. The duration and the severity of the responses induced by stimulations during the acquisition period are reduced.